Impacts of gut microbiota on gestational diabetes mellitus: a comprehensive review.

European Journal of Nutrition
Lingling HuangSiriporn C Chattipakorn

Abstract

Gestational diabetes mellitus (GDM) is a condition that seriously threatens mother and child health. The incidence of GDM has increased worldwide in the past decades. In addition, the complications of GDM such as type 2 diabetes (T2DM) and neonatal malformations could negatively affect the living quality of mothers and their children. It has been widely known that the imbalance of gut microbiota or called 'gut dysbiosis' plays a key role in the development of insulin resistance and chronic low-grade inflammation in T2DM patients. However, the impacts of gut microbiota on GDM remain controversial. Here, we aim to comprehensively review the alterations of gut microbiota in GDM mothers and their offspring. The alterations of Firmicutes/Bacteroidetes (F/B) ratio, short-chain fatty acid (SCFA)-producing bacteria, bacteria with probiotics properties and gram-negative lipopolysaccharide (LPS)-producing bacteria play a vital role in the development of GDM. The beneficial roles of gut microbiota modification (probiotics, synbiotics and lifestyle modification) as a treatment of GDM were found in some, but not all studies. In the near future, gut microbiota modification may be considered as one of the standard treatments for GDM. Moreover...Continue Reading

References

Feb 26, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Betty R Vohr, Charlotte M Boney
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maria G Dominguez-BelloRob Knight
Dec 21, 2010·The Journal of Nutritional Biochemistry·Marco A R VinoloRui Curi
Feb 11, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Sven SchneiderHolger Maul
Jun 22, 2012·PloS One·Susan M HuseAnthony A Fodor
May 28, 2014·FEMS Microbiology Reviews·Mirjana Rajilić-Stojanović, Willem M de Vos
Sep 7, 2014·Diabetologia·Jennifer HuynhRhonda Bentley-Lewis
Apr 15, 2015·JAMA : the Journal of the American Medical Association·Anny H XiangDarios Getahun
Sep 17, 2016·Advances in Nutrition·Kathene C Johnson-HenryPhilip M Sherman
Nov 15, 2016·Current Opinion in Immunology·Charles V Rosadini, Jonathan C Kagan
Aug 9, 2017·Probiotics and Antimicrobial Proteins·Maryam KaramaliZatollah Asemi
Sep 1, 2017·Immunological Reviews·Jeremy J Barr
Sep 30, 2017·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Neda RoshanravanAlireza Ostadrahimi
Oct 21, 2017·Metabolism: Clinical and Experimental·Ling-Jun LiEcosse Lamoureux
Nov 28, 2017·Methods in Molecular Biology·Yamel Cardona GloriaDominic De Nardo
Jan 10, 2018·Scientific Reports·P LarraufieH M Blottiere
Feb 14, 2018·Advances in Nutrition·Hu LiuXi Ma
Apr 11, 2018·Cancer Cell·Vancheswaran GopalakrishnanJennifer A Wargo
Apr 18, 2018·Diabetes & Metabolic Syndrome·Nazarii KobyliakIuliia Komissarenko
Sep 8, 2018·GigaScience·Fei LiHuijue Jia
Nov 14, 2018·Endocrine·Ramon V CortezSilvia Daher
Jan 19, 2019·Diabetes Care·William L LoweUNKNOWN HAPO Follow-up Study Cooperative Research Group

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Citations

May 1, 2021·International Journal of Molecular Sciences·Karina PolakNorbert Kiss

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