Impacts of L1 Promoter Variation and L2 Clavulanate Susceptibility on Ticarcillin-Clavulanate Susceptibility of Stenotrophomonas maltophilia

Antimicrobial Agents and Chemotherapy
Hsin-Hui HuangTsuey-Ching Yang

Abstract

Inducible expression of L1 and L2 β-lactamases is the principal mechanism responsible for β-lactam resistance in Stenotrophomonas maltophilia Ticarcillin-clavulanate (TIM) is one of the few effective β-lactams for S. maltophilia treatment. Clavulanate (CA) is a β-lactamase inhibitor that specifically targets class A, C, and D β-lactamases. In view of the presence of class B L1 β-lactamase, it is of interest to elucidate why TIM is valid for S. maltophilia treatment. The L1-L2 allelic variation and TIM susceptibilities of 22 clinical isolates were established. Based on L1 and L2 protein sequences and TIM susceptibility, three L1-based phylogenetic clusters (L1-A, L1-B, and L1-C) and three L2-based phylogenetic clusters (L2-A, L2-B1, and L2-B2) were classified. The contribution of each L1- and L2-based phylogenetic cluster to ticarcillin (TIC) and TIM susceptibility was investigated. All the L1s and L2s tested contributed to TIC resistance. The L1s tested were inert to CA; nevertheless, the sensitivities of L2s to CA were widely different. In addition, the genetic organizations upstream of the L1 gene varied greatly in these isolates. At least three different L1 promoter structures (K279a type, D457 type, and none) were found amo...Continue Reading

References

Mar 1, 1984·Antimicrobial Agents and Chemotherapy·Y SainoS Mitsuhashi
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·Y SainoS Mitsuhashi
May 21, 1998·Antimicrobial Agents and Chemotherapy·F SanschagrinR C Levesque
Nov 11, 1999·International Journal of Systematic Bacteriology·L HaubenJ Swings
Jun 1, 2000·Infectious Disease Clinics of North America·L M Bush, C C Johnson
Oct 5, 2002·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Paola Sandra MercuriMoreno Galleni
Jan 24, 2008·Antimicrobial Agents and Chemotherapy·Aki Okazaki, Matthew B Avison
Feb 12, 2009·Journal of Medical Microbiology·Rouh-Mei HuTsuey-Ching Yang
May 6, 2009·Antimicrobial Agents and Chemotherapy·Tsuey-Ching YangYu-Tzu Lin
Aug 8, 2009·Future Microbiology·Maria B SanchezJose L Martinez
Jan 13, 2010·Clinical Microbiology Reviews·Sarah M Drawz, Robert A Bonomo
Jan 19, 2012·Antimicrobial Agents and Chemotherapy·Yi-Wei HuangTsuey-Ching Yang
Jun 13, 2012·Journal of Bacteriology·Felipe LiraJosé L Martínez
Jul 31, 2013·Mini Reviews in Medicinal Chemistry·Jiao ChenWenbing Yao
Dec 17, 2015·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Elias B ChahineRaquel Ortiz

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Citations

Apr 4, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Sz-Yun PanTsuey-Ching Yang
May 1, 2021·International Journal of Molecular Sciences·Qian-Qian LiDong-Yeul Kwon
Sep 7, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lu HanJian Sun

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