Impacts of maternal dietary protein intake on fetal survival, growth, and development

Experimental Biology and Medicine
Cassandra HerringGuoyao Wu

Abstract

Maternal nutrition during gestation, especially dietary protein intake, is a key determinant in embryonic survival, growth, and development. Low maternal dietary protein intake can cause embryonic losses, intra-uterine growth restriction, and reduced postnatal growth due to a deficiency in specific amino acids that are important for cell metabolism and function. Of note, high maternal dietary protein intake can also result in intra-uterine growth restriction and embryonic death, due to amino acid excesses, as well as the toxicity of ammonia, homocysteine, and H2S that are generated from amino acid catabolism. Maternal protein nutrition has a pronounced impact on fetal programming and alters the expression of genes in the fetal genome. As a precursor to the synthesis of molecules (e.g. nitric oxide, polyamines, and creatine) with cell signaling and metabolic functions, L-arginine (Arg) is essential during pregnancy for growth and development of the conceptus. With inadequate maternal dietary protein intake, Arg and other important amino acids are deficient in mother and fetus. Dietary supplementation of Arg during gestation has been effective in improving embryonic survival and development of the conceptus in many species, inclu...Continue Reading

References

Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·B BlondeauB Bréant
Jul 12, 2003·Biology of Reproduction·Hyukjung KwonThomas E Spencer
Apr 28, 2004·Trends in Endocrinology and Metabolism : TEM·Peter D Gluckman, Mark A Hanson
Aug 31, 2004·The Journal of Nutrition·Guoyao WuThomas E Spencer
Jan 31, 2006·The Proceedings of the Nutrition Society·Simon C Langley-Evans
Jul 22, 2008·The Journal of Nutrition·Xiangfang ZengJunjun Wang
May 28, 2010·The Journal of Nutrition·Arantzatzu LassalaGuoyao Wu
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Guoyao WuAmy Webb Girard
Sep 13, 2012·Journal of Pregnancy·R E FisherN A Karrow
Oct 5, 2012·The American Journal of Clinical Nutrition·Michelle L BlumfieldClare E Collins
Feb 22, 2013·Biology of Reproduction·Francesca MossaAlexander C O Evans
Jul 8, 2014·Journal of Animal Science and Biotechnology·Guoyao Wu
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Olena BabenkoGerlinde A S Metz
Jun 5, 2015·Experimental Biology and Medicine·Yongqing HouGuoyao Wu
Jan 23, 2016·Food & Function·Guoyao Wu
May 9, 2016·Amino Acids·Zhenlong WuGuoyao Wu
Sep 2, 2016·The American Journal of Clinical Nutrition·Karen M SwitkowskiEmily Oken
Jan 18, 2017·Advances in Nutrition·Yongqing Hou, Guoyao Wu
Apr 9, 2017·Molecular Reproduction and Development·Guoyao WuXiaolong Wang
May 10, 2017·Journal of Animal Science and Biotechnology·Yun JiGuoyao Wu

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Citations

Jan 24, 2019·Journal of Clinical Medicine·Rossella AttiniGiorgina Barbara Piccoli
Apr 30, 2019·Journal of Tropical Pediatrics·Victor Chung PamStephen Oguche
May 16, 2019·Experimental Biology and Medicine·Pavel SvitokMichal Zeman
Nov 14, 2019·Nutrients·Valentine Suzanne Moullé, Patricia Parnet
Jun 18, 2020·Nutrients·Chien-Ning Hsu, You-Lin Tain
Nov 17, 2020·Nutrition Reviews·Guadalupe Estrada-GutiérrezFelipe Vadillo-Ortega
Nov 10, 2020·Journal of Animal Science·Joel S CatonLawrence P Reynolds
Jan 9, 2021·Frontiers in Pharmacology·Tarique HussainYulong Yin
Feb 16, 2021·Journal of Animal Science and Biotechnology·William H E J van WettereSimon K Walker
Nov 22, 2020·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain
Apr 2, 2021·Epigenetics & Chromatin·Yinyu WangHefeng Huang
May 7, 2020·Cell Metabolism·Aharon HelmanDouglas A Melton
Jun 2, 2021·Journal of Tropical Pediatrics·Rafaela Cristina Vieira E SouzaLuana Caroline Dos Santos
Jan 22, 2021·Public Health Nutrition·Sorayya Kheirouri, Mohammad Alizadeh
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Sarah McCoskiCarla Sanford

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