Impacts of short-term food restriction on immune development in altricial house sparrow nestlings

Physiological and Biochemical Zoology : PBZ
Tess L KillpackWilliam H Karasov

Abstract

Food limitation is a common ecological scenario for nestling altricial birds, and reductions in growth and maintenance have been observed in resource-limited nestlings. Substantial development of the immune system occurs during the nestling period, yet the resource dependence of this immune development is understudied. We examined constitutive immune system development as well as acute-phase responses to lipopolysaccharide (LPS) injection after 48 h of food restriction in house sparrows at 7 and 13 d posthatch. We also examined nestlings that were restricted early (5-7 d) but refed and tested at 13 d posthatch to determine whether altered immune function and growth early in the nestling period were recovered upon return to adequate resource supply. Induced acute-phase protein response was reduced in food-restricted birds, yet no lasting reductions in acute-phase protein levels were observed in previously restricted nestlings that were challenged with LPS after refeeding. Food restriction did not significantly impact constitutive levels of complement-mediated lysis or circulating IgY antibodies. As a comparator to immune measures, we found that organ and tarsus size, as well as muscle size and citrate synthase enzyme activity (a...Continue Reading

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Dec 2, 2004·Developmental and Comparative Immunology·Kevin D MatsonKirk C Klasing
Jul 28, 2006·Developmental and Comparative Immunology·Sam MilletKirk C Klasing
Oct 14, 2008·Developmental and Comparative Immunology·Maria G PalaciosCarol M Vleck
Apr 21, 2009·The Journal of Experimental Biology·Paweł BrzekWilliam H Karasov
May 5, 2010·The American Journal of Tropical Medicine and Hygiene·Valerie A O'BrienCharles R Brown
Jul 12, 2011·Physiological and Biochemical Zoology : PBZ·Sophie BourgeonTony D Williams
Feb 10, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kevin D MatsonB Irene Tieleman
Mar 20, 2014·Physiological and Biochemical Zoology : PBZ·Sandra Sköld-ChiriacDennis Hasselquist

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Citations

Jan 23, 2018·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Elisabeth MacCollCynthia J Downs
Aug 14, 2018·General and Comparative Endocrinology·Emily E Virgin, Kimberly A Rosvall
Aug 11, 2021·Proceedings. Biological Sciences·J C OwenL D Kramer

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