Impacts of Simulated Weightlessness by Dry Immersion on Optic Nerve Sheath Diameter and Cerebral Autoregulation

Frontiers in Physiology
Marc KermorgantAnne Pavy-Le Traon

Abstract

Dry immersion (DI) is used to simulate weightlessness. We investigated in healthy volunteers if DI induces changes in ONSD, as a surrogate marker of intracranial pressure (ICP) and how these changes could affect cerebral autoregulation (CA). Changes in ICP were indirectly measured by changes in optic nerve sheath diameter (ONSD). 12 healthy male volunteers underwent 3 days of DI. ONSD was indirectly assessed by ocular ultrasonography. Cerebral blood flow velocity (CBFV) of the middle cerebral artery was gauged using transcranial Doppler ultrasonography. CA was evaluated by two methods: (1) transfer function analysis was calculated to determine the relationship between mean CBFV and mean arterial blood pressure (ABP) and (2) correlation index Mxa between mean CBFV and mean ABP.ONSD increased significantly during the first day, the third day and the first day of recovery of DI (P < 0.001).DI induced a reduction in Mxa index (P < 0.001) and an elevation in phase shift in low frequency bandwidth (P < 0.05). After DI, Mxa and coherence were strongly correlated with ONSD (P < 0.05) but not before DI. These results indicate that 3 days of DI induces significant changes in ONSD most likely reflecting an increase in ICP. CA was improved...Continue Reading

References

Oct 1, 1991·Journal of Clinical Pharmacology·C S LeachJ B Charles
Oct 1, 1991·Journal of Clinical Pharmacology·J B Charles, C M Lathers
Oct 1, 1995·Stroke; a Journal of Cerebral Circulation·R R DiehlP Berlit
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·M CzosnykaJ D Pickard
Nov 13, 2001·Journal of Neurosurgery·M CzosnykaJ D Pickard
May 15, 2002·Clinical Physiology and Functional Imaging·Anne Pavy-Le TraoMarc Parant
Jul 2, 2003·Journal of Applied Physiology·William H CookeOlga A Kovalenko
Aug 29, 2006·Autonomic Neuroscience : Basic & Clinical·Martina Heer, William H Paloski
Dec 23, 2006·The Journal of Physiology·Ken-ichi IwasakiC Gunnar Blomqvist
Jul 31, 2007·European Journal of Applied Physiology·A Pavy-Le TraonJ Vernikos
May 15, 2008·Critical Care : the Official Journal of the Critical Care Forum·Theodoros SoldatosAndreas Karabinis
Jun 3, 2008·Neurologic Clinics·Leonardo Rangel-CastillaClaudia S Robertson
Sep 13, 2008·Critical Care : the Official Journal of the Critical Care Forum·Thomas GeeraertsDavid K Menon
May 22, 2009·Aviation, Space, and Environmental Medicine·Yojiro OgawaSetsuro Ogawa
Dec 17, 2010·European Journal of Applied Physiology·Nastassia M NavasiolavaInesa B Kozlovskaya
May 28, 2011·Stroke; a Journal of Cerebral Circulation·Andrew P BlaberMahmood S Kassam
Jun 23, 2011·British Journal of Anaesthesia·C DubostT Geeraerts
Mar 15, 2012·Radiology·Larry A KramerDouglas R Hamilton
Apr 12, 2012·American Journal of Physiology. Heart and Circulatory Physiology·K A ZujR L Hughson
Jul 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Y C TzengC A Rickards
Sep 5, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Nathalie NasrVincent Larrue
Nov 12, 2014·Life·Emily S NelsonJerry G Myers
Jan 20, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jurgen A H R ClaassenUNKNOWN international Cerebral Autoregulation Research Network (CARNet)
Feb 13, 2016·Journal of Applied Physiology·Donald E Watenpaugh
Jan 17, 2017·The Journal of Physiology·Justin S LawleyBenjamin D Levine

❮ Previous
Next ❯

Citations

Apr 12, 2019·Frontiers in Physiology·Elena TomilovskayaInessa Kozlovskaya
Jul 14, 2020·Frontiers in Physiology·Meenakshi Pandiarajan, Alan R Hargens
Jul 29, 2020·Frontiers in Physiology·Marc KermorgantAnne Pavy-Le Traon
Feb 2, 2021·Frontiers in Physiology·Alexander Yu MeigalIrina V Sayenko
Aug 3, 2021·Frontiers in Physiology·Marc KermorgantVincent Soler

❮ Previous
Next ❯

Software Mentioned

PDL

Related Concepts

Related Feeds

Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.