Impacts of the 13-Valent Pneumococcal Conjugate Vaccine in Children

Journal of Immunology Research
Susanna Esposito, Nicola Principi

Abstract

Applications of the heptavalent pneumococcal conjugate vaccine (PCV7) in the pediatric immunization schedule have dramatically reduced the incidence of pneumococcal diseases in both vaccinated children and unvaccinated individuals of all ages. However, increased infections caused by non-PCV7 serotypes have been reported by several groups. To overcome this problem, new vaccines covering more serotypes including the emerging serotypes have been developed. The 13-valent pneumococcal conjugate vaccine (PCV13) currently covers the 7 PCV7 serotypes (4, 6B, 9V, 14, 18C, 19F, and 23F) and 6 additional serotypes 1, 3, 5, 6A, 7F, and 19A. After the first year of PCV13 applications in the immunization schedule in young children, global evaluation studies demonstrated that PCV13 provided a wider coverage and more effective prevention than PCV7 against invasive pneumococcal diseases (IPDs), mucosal pneumococcal diseases, and pneumococcal carriage. We reviewed the effects of PCV13 in the control of pneumococcal diseases in children based on previous studies.

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Citations

Oct 3, 2017·Biomédica : revista del Instituto Nacional de Salud·Paola Andrea PalaciosJaime Moreno
Jul 4, 2019·Journal of Medical Microbiology·Lucia Gonzales-SilesEdward R B Moore
Mar 1, 2016·Expert Opinion on Drug Safety·Susanna Esposito, Nicola Principi
Apr 19, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Justin LoloiJohnathan D McGinn
Mar 11, 2020·Frontiers in Pediatrics·Dominik OchocinskiNiranjan Kissoon
Dec 19, 2020·FEMS Microbiology Reviews·Tong SuLok-To Sham
Nov 24, 2016·The Pediatric Infectious Disease Journal·Tal MaromSharon Ovnat Tamir
Jul 23, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shalom Ben-ShimolUNKNOWN Israeli Pediatric Bacteremia And Meningitis Group (Ipbmg), And The Israeli Adult Invasive Pneumococcal Disease (Iaipd) Group

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