Abstract
Seventy-five SD rats were randomly assigned to four groups: sham-operated group (Sham, n = 15), complete spinal cord transection (CSCT, n = 20) group, hyperbaric oxygenation group 1 (HBO1, n = 20), and hyperbaric oxygenation group 2 (HBO2, n = 20). The aim of this study was to analyze the impacts of ultra-early hyperbaric oxygen therapy on bone mass of rats with CSCT. Treatment of patients with complete SCI is still an unresolved medical issue and needs to be further investigated. Studies on changes in bone mass as well as osteoporosis prevention after SCI have important clinical significance. Rats in the sham group only underwent T10 laminectomy, without damaging the spinal cord. Rats in CSCT, HBO1, and HBO2 groups underwent T10 laminectomy and spinal cord transection at T10 level. Rats in HBO1 and HBO2 groups received three courses of hyperbaric oxygen therapy with 10 days per course starting at 3 and 12 hours after spinal cord injury, respectively. The femoral biomechanical characteristics, the bone calcium, and the bone hydroxyproline (B-HYP) contents were determined. Morphology of the femur bone trabecula and the bone collagen were observed by HE staining and by masson triad color staining, respectively. After 6 weeks of t...Continue Reading
References
Jul 12, 1990·The New England Journal of Medicine·N B WattsM J Yanover
Jan 1, 1995·Bone·C H SøgaardR Ziegler
Mar 12, 1998·The New England Journal of Medicine·R Eastell
Nov 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y JiangH K Genant
Oct 14, 2003·Journal of Applied Physiology·Ego Seeman
Oct 14, 2004·The Journal of Spinal Cord Medicine·Douglas E GarlandCharles Stewart
Sep 1, 2005·Journal of Bone and Mineral Metabolism·Koko OgawaToyozo Sakurada
Oct 12, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Sheng-Dan JiangLei-Sheng Jiang
Mar 5, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M E RuppelD B Burr
Apr 17, 2008·The Proceedings of the Nutrition Society·Richard Eastell, Rosemary A Hannon
Aug 5, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Samar Hamid, Ray Hayek
May 14, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ShenJ M Hu
Dec 17, 2009·Journal of Psychosocial Nursing and Mental Health Services·Cheng-I ChuJung Lin