PMID: 9177879Mar 1, 1997Paper

Impaired actin polymerization and depolymerization in neutrophils from patients with thermal injury

Burns : Journal of the International Society for Burn Injuries
H A Vindenes, R Bjerknes

Abstract

Acquired neutrophil dysfunction is considered an important cause of increased susceptibility to infection in patients with burns. In the early postinjury phase, large amounts of circulating chemo-attractants, cytokines and endotoxins induce strong systemic activation of neutrophils which may impair their motile functions. Actin is the most prevalent component of the microfilament lattice that generates force for the neutrophil motile responses, and in the present study we examined the dynamics of actin polymerization and depolymerization in neutrophils from 11 patients with large burns. At admission, the amount of polymerized actin in unstimulated neutrophils was 39.9 per cent higher than that of parallel controls. In addition, there was a positive correlation between the amount of polymerized actin and the total body surface area (TBSA) burn. The time course of patient neutrophil actin polymerization in response to FMLP, C5a, (Ser-IL-8)72, (Ala-IL-8)77 and crosslinking of surface Fc gamma RII was similar to that of controls, and the maximal amount of neutrophil F-actin was demonstrated after 30 s stimulation. At the peak of actin polymerization, however, patient neutrophils contained 27.3, 24.0, 24.7 and 25.6 per cent more pol...Continue Reading

References

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Citations

Oct 31, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Pi-hong ZhangXiao-Yuan Huang
Jan 5, 2000·Journal of Immunological Methods·S F van EedenJ C Hogg
Jun 20, 2006·Shock·Celeste C FinnertyMarc G Jeschke
Dec 19, 2006·Shock·Celeste C FinnertyMarc G Jeschke
Feb 20, 2007·Critical Care : the Official Journal of the Critical Care Forum·Celeste C FinnertyMarc G Jeschke
Apr 30, 2003·Cytometry. Part B, Clinical Cytometry·George F Babcock
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus S Huber-LangPeter A Ward
Nov 21, 2008·Cytokine·Celeste C FinnertyMarc G Jeschke

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