Impaired actions of insulin-like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect

The Journal of Clinical Investigation
H DingJ D Kopple

Abstract

The actions of insulin-like growth factor 1 (IGF-1) on protein turnover and of the IGF-1 receptor (IGF-1R) were examined in skeletal muscle of rats with chronic renal failure (CRF) and sham operated (SO), pair-fed controls. Acidemia was prevented in CRF rats with NaHCO3. Serum IGF-1 and skeletal muscle IGF-1 and IGF-1 mRNA were reduced in CRF rats. Dose-response studies revealed impaired stimulation of protein synthesis and suppressed inhibition of protein degradation by IGF-1 in epitrochlearis muscle of CRF rats. Neither IGF-1 analogues with low affinity to IGF binding proteins nor proteinase inhibitors obliterated the IGF-1 resistance. In CRF rats, skeletal muscle IGF-1R mRNA was increased; displacement ligand binding studies and affinity labeling of the IGF-1R alpha subunit indicated increased total skeletal muscle IGF-1R number with normal affinity. However, both autophosphorylation of the IGF-1R beta subunit (i.e., IGF-1R tyrosine kinase) and the IGF-1R tyrosine kinase activity towards exogenous insulin receptor substrate-1, a natural substrate for IGF-1R tyrosine kinase, were reduced in CRF fats. These data indicate that in skeletal muscle of CRF rats there is resistance to the IGF-1 effects on protein synthesis and degra...Continue Reading

References

Sep 1, 1977·The Journal of Clinical Investigation·R W FurlanettoA J D'Ercole
Jul 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·W F BlumO Mehls
Jan 1, 1991·Acta Paediatrica Scandinavica. Supplement·P D GluckmanJ H Shaw
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H WernerD LeRoith
Jan 1, 1989·Progress in Growth Factor Research·R C Baxter, J L Martin
Jan 1, 1985·Annual Review of Physiology·M M Rechler, S P Nissley
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W L LoweD LeRoith
Jun 1, 1986·Kidney International·J B Li, S J Wassner
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A J D'ErcoleL E Underwood
Nov 1, 1981·Metabolism: Clinical and Experimental·L S Phillips, J D Kopple
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·M O SavageR G Rosenfeld
Feb 1, 1994·Endocrine Reviews·J P ThissenL E Underwood
Jan 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S G Massry, G Z Fadda
Jan 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W E MitchB K England
May 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G SchulmanR M Hakim

❮ Previous
Next ❯

Citations

Feb 5, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ralph RabkinFranz Schaefer
Aug 7, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shefali Mahesh, Frederick Kaskel
Jul 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ralph Rabkin, Franz Schaefer
Aug 7, 2002·International Journal of Cardiology·Marijke BrinkPatrick Delafontaine
May 13, 1999·Nutrition·Y Ingenbleek, L Bernstein
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·C BotfieldC J Hinds
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Gudmundur Johannsson, Jarl Ahlmén
Sep 29, 2011·Nature Reviews. Nephrology·Lesley Rees, Robert H Mak
Nov 14, 2002·British Journal of Pharmacology·Carl GuévinVincent Pichette
Jan 14, 2000·Kidney International. Supplement·J A Hoyland, M L Picton
Mar 29, 2002·Kidney International·Juan F NavarroJavier García
Jan 20, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Franz Schaefer
Jul 14, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joel D KoppleTalat Alp Ikizler
May 9, 2001·Current Opinion in Nephrology and Hypertension·K Sakhaee
Jun 18, 2004·Kidney International·Benito AmilFernando Santos
Feb 9, 2005·Kidney International·Zhilan ZhengRalph Rabkin
Dec 1, 2005·Kidney International·Andrew B LemmeyMahdi Jibani
Jan 1, 1997·The Journal of Clinical Investigation·G GaribottoA Tizianello
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Yves Ingenbleek, Vernon R Young
Apr 18, 2008·Journal of the American Society of Nephrology : JASN·Emilie SimardVincent Pichette
Nov 6, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Ouppatham SupasyndhJoel D Kopple
Feb 23, 2013·ISRN Endocrinology·James L Bailey
Apr 9, 2014·BMC Nephrology·Wei Chen, Matthew K Abramowitz
Jul 2, 2014·Nature Reviews. Nephrology·Xiaonan H Wang, William E Mitch
Apr 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ibrahim H Fahal
Feb 9, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Matthew K AbramowitzThomas H Hostetter
Jun 10, 2015·Journal of the American Society of Nephrology : JASN·Hui PengZhaoyong Hu
Oct 24, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Joel D KoppleT Alp Ikizler
Aug 13, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wei Chen, Matthew K Abramowitz
Apr 1, 2011·Journal of the American Medical Directors Association·Claudio PedoneRaffaele Antonelli Incalzi
Sep 10, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·S Russ PriceTiffany K Roberts-Wilson
Dec 3, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ying KuanJohn L Haylor
Feb 13, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S R PriceW E Mitch
Jan 7, 2004·Advances in Renal Replacement Therapy·Rajnish Mehrotra, Joel D Kopple
Feb 9, 2005·British Journal of Pharmacology·Josée MichaudVincent Pichette
Jan 22, 2005·Seminars in Dialysis·Kamyar Kalantar-ZadehJoel D Kopple

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