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Impaired activation of lesional CD8+ T-cells is associated with enhanced expression of Programmed Death-1 in Indian Post Kala-azar Dermal Leishmaniasis

Scientific Reports

Jan 27, 2019

Shibabrata MukherjeeMitali Chatterjee

Abstract

Post Kala-azar dermal leishmaniasis (PKDL), caused by Leishmania donovani is the dermal sequel of Visceral Leishmaniasis and importantly, is the proposed disease reservoir. The survival of Leishmania parasites within monocytes/macrophages hinges on its ability to effectively nullify imm...read more

Mentioned in this Paper

Study
T-Lymphocyte
Perforin
CCL17
Interleukin-1
CCRN4L gene
Dermis
GZMA
PKD2L1 protein, human
CD8-Positive T-Lymphocytes
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Impaired activation of lesional CD8+ T-cells is associated with enhanced expression of Programmed Death-1 in Indian Post Kala-azar Dermal Leishmaniasis

Scientific Reports

Jan 27, 2019

Shibabrata MukherjeeMitali Chatterjee

PMID: 30679687

DOI: 10.1038/s41598-018-37144-y

Abstract

Post Kala-azar dermal leishmaniasis (PKDL), caused by Leishmania donovani is the dermal sequel of Visceral Leishmaniasis and importantly, is the proposed disease reservoir. The survival of Leishmania parasites within monocytes/macrophages hinges on its ability to effectively nullify imm...read more

Mentioned in this Paper

Study
T-Lymphocyte
Perforin
CCL17
Interleukin-1
CCRN4L gene
Dermis
GZMA
PKD2L1 protein, human
CD8-Positive T-Lymphocytes

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