PMID: 1193415Nov 1, 1975Paper

Impaired anamnestic cellular immune response in patients with Crohn's disease

Gut
S G MeuwissenG N Tytgat

Abstract

The cellular immune system was studied in patients with Crohn's disease (CD), not receiving corticosteroids, or azathioprine, by means of in vitro and in vivo methods. It was found, that the in vitro lymphocyte reactivity of 54 CD patients after stimulation with a cocktail of antigens (varidase, trichophyton, candida, mumps, and PPD) was significantly depressed when compared with the response of 20 simultaneously cultured healthy controls (p less than 0-001) or a group of 54 separately cultured healthy controls, matched for age and sex (p less than 0-001). The lymphocyte response of a control group of 18 patients with malnutrition or malabsorption without any evidence of inflammatory bowel disease, was higher than the response of an equal number of CD cases, although the difference failed to reach significance. Intradermally injection of the same five antigens, as used in the antigen cocktail, showed a failure to react to any antigen in 13 out of 48 CD patients, in comparison with three of 48 matched healthy controls (p less than 0-01). In both CD patients, as well as in healthy controls a significant correlation could be demonstrated between the number of positive skin tests, the area of skin induration, and the in vitro lymph...Continue Reading

References

Oct 7, 1967·Lancet·J Fletcher, J M Hinton
Jan 1, 1973·Vox Sanguinis·B HouwenH O Nieweg
Jan 1, 1972·Scandinavian Journal of Gastroenterology·C Röpke
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Jul 1, 1966·The American Journal of Digestive Diseases·H J BinderW R Thayer

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Citations

Nov 1, 1986·Journal of Clinical Immunology·W Strober, S P James
Apr 1, 1978·The American Journal of Digestive Diseases·W R ThayerC E Field
Jul 1, 1987·Diseases of the Colon and Rectum·J K TriantafillidisP Efthymiou
May 16, 2012·Nature Reviews. Gastroenterology & Hepatology·Franck CarboneroH Rex Gaskins
Jan 29, 1977·British Medical Journal
Jul 10, 1976·British Medical Journal·R P Ng, F R Vicary
Jan 1, 1981·Scandinavian Journal of Gastroenterology·M PfreundschuhJ D Beck
Jan 1, 1979·Scandinavian Journal of Gastroenterology·C J MeijerJ Lindeman
Jan 1, 1978·Scandinavian Journal of Gastroenterology·U KrauseL Juhlin
Feb 1, 1983·American Journal of Surgery·T HeimannA H Aufses
Feb 1, 1981·Medical Hypotheses·B S Rabin, G Singh
Mar 1, 1986·American Journal of Surgery·P I TartterA H Aufses
Mar 1, 1990·Digestive Diseases and Sciences·J A AwadR E Clouse
Jan 1, 1978·Scandinavian Journal of Gastroenterology·I O AuerH Sommer
Oct 15, 1979·Klinische Wochenschrift·E TönnesmannK Federlin

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