PMID: 6160858Nov 1, 1980Paper

Impaired antigen-specific suppressor cell activity in patients with rheumatoid arthritis

Arthritis and Rheumatism
E C KeystoneL Poplonski

Abstract

Antigen-specific suppressor cell activity of peripheral blood mononuclear cells was investigated in 20 patients with rheumatoid arthritis (RA) and 16 age- and sex-matched healthy controls. Suppressor cell activity was generated by priming peripheral blood mononuclear cells with high dose antigen (ovalbumin) and adding the washed primed or control (unprimed) cells to autologous, optimally stimulated, target plaque forming cell (PFC) cultures. The ability of the primed cells to interfere with an optimal ovalbumin specific PFC response in the target culture was used as a measure of antigen-specific suppressor cell activity. The results demonstrated that the mean (+/- SE) PFC response of the rheumatoid patients (669 +/- 76 PFC/10(6) cells) was not statistically different from that of the normal controls (722 +/- 83 PFC/10(6) cells), P = 0.1. However, reduced suppressor cell activity was observed in the rheumatoid patients relative to controls (46.4 +/- 4.2% versus 64.6 +/- 2.7% suppression, respectively; P < 0.001). No correlation was demonstrated between suppressor cell activity in rheumatoid patients and disease activity or therapy.

References

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Citations

Jan 1, 1990·Journal of Clinical Laboratory Analysis·A B CarpenterS H Ip
Oct 1, 1981·Journal of Clinical Immunology·G C Tsokos, J E Balow
Apr 1, 1982·Journal of Clinical Immunology·T SakaneT Tsunematsu
Sep 1, 1988·Journal of Clinical Immunology·M R LieblingJ S Louie
Dec 13, 2012·The Journal of Antibiotics·Hiroyuki KumagaiDaishiro Ikeda
Nov 18, 1982·The New England Journal of Medicine·K T Nouri-AriaR Williams
Nov 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T YamamotoT Osaki
Dec 1, 1994·Annals of the Rheumatic Diseases·Y UekiY Tominaga
Jan 1, 1981·Annals of the New York Academy of Sciences·A L GoldsteinR Jacobs
Feb 1, 1984·Journal of Oral Pathology·A Pedersen, B Klausen
Oct 1, 1983·Scandinavian Journal of Immunology·T EgelandO J Mellbye
Sep 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R WoodH Markowitz
Jul 1, 1985·Medicinal Research Reviews·V J StecherD M Bailey
Feb 1, 1982·Arthritis and Rheumatism·C J ShamessE C Keystone
Mar 1, 1982·Arthritis and Rheumatism·L SkoldstamR Messner

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