Impaired arterial baroreflex function before nitrate-induced vasovagal syncope during head-up tilt test

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Massimo IacovielloStefano Favale

Abstract

The aim of this study was to evaluate arterial baroreflex control of heart rate immediately before head-up tilt test (HUT)-induced vasovagal syncope (VVS). We enrolled 97 otherwise healthy subjects with recurrent unexplained syncope. After 10 min of rest in supine position, they underwent a passive HUT potentiated with nitroglycerin administration after 20 min. Beat-to-beat heart rate and systolic blood pressure were continuously recorded. Sequence method was used to measure two complementary parameters reflecting arterial baroreflex control of heart rate: the baroreflex sensitivity (BRS) and the baroreflex effectiveness index (BEI). Twenty-one patients fainted before nitrate administration (HUT+) and 37 after nitrate administration (NTG+). Immediately before syncope, the NTG+ patients showed significantly lower BRS values than those observed at the end of the test in the patients without syncope (5.5 +/- 2.8 vs. 7.7 +/- 3.4 ms/mmHg; P = 0.004) and a significantly lower BEI (30 +/- 20% vs. 53 +/- 24%; P < 0.001). The HUT+ patients did not show any significant differences in BRS and BEI before syncope from the values observed during the corresponding tilt period in the other groups. A significant depression in BRS and BEI occurs...Continue Reading

References

Apr 1, 1968·Circulation·S E EpsteinG D Beiser
Dec 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A LagiA Macerata
Dec 1, 1993·The American Journal of Cardiology·J F SneddonM Malik
Jan 21, 1997·Circulation·H L ThomsonM Frenneaux
Mar 1, 1997·Pacing and Clinical Electrophysiology : PACE·K A EllenbogenM L Smith
Jun 1, 1997·The Journal of Clinical Investigation·R Mosqueda-GarciaD Robertson
Aug 1, 1997·Journal of Applied Physiology·L A LipsitzA Medina
Feb 26, 2000·Cardiovascular Research·J Zanzinger
May 12, 2000·Journal of the American College of Cardiology·W K ShenS C Hammill
Jan 11, 2000·Circulation·R Mosqueda-GarciaR Fernandez-Violante
Feb 28, 2001·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·J FreitasA Falcão de Freitas
Apr 8, 2003·Journal of the American College of Cardiology·Mariavittoria PitzalisPaolo Rizzon
Apr 8, 2003·The Journal of Physiology·P O O JuluR Hainsworth
Dec 31, 2003·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Nemer SamniahDavid G Benditt
Feb 10, 2004·Journal of Applied Physiology·Tomi LaitinenJuha Hartikainen
Sep 11, 2004·Journal of the American College of Cardiology·Janneke GisolfJohn M Karemaker
Nov 3, 2004·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michele BrignoleUNKNOWN Task Force on Syncope, European Society of Cardiology

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Citations

Apr 16, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Sandro SorrentinoStefano Favale
Jul 1, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Massimo IacovielloStefano Favale
Feb 20, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Sandro SorrentinoStefano Favale
May 22, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Massimo IacovielloStefano Favale
Feb 5, 2010·Autonomic Neuroscience : Basic & Clinical·Sandro SorrentinoStefano Favale
Nov 8, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Matjaž Klemenc, Erik Štrumbelj
Mar 5, 2014·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Erdal GursulKamil Tuluce
Jun 26, 2010·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Thomas RitzErica S Ayala
Jun 4, 2016·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·João Fernandes SerôdioRui Cruz Ferreira
Oct 13, 2017·Pacing and Clinical Electrophysiology : PACE·Sung Ho LeeJune Soo Kim
Nov 18, 2017·Pacing and Clinical Electrophysiology : PACE·Peter MitroErvin Muller
Sep 23, 2021·Kardiologiia·Sinan Akıncıİbrahim Haldun Müderrisoğlu

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Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Sandro SorrentinoStefano Favale
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Nemer SamniahDavid G Benditt
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