Impaired aspirin-mediated platelet function inhibition in resuscitated patients with acute myocardial infarction treated with therapeutic hypothermia: a prospective, observational, non-randomized single-centre study

Annals of Intensive Care
Florian PrüllerDirk von Lewinski

Abstract

The majority of resuscitated patients present with underlying cardiac disease, and out of these myocardial infarction is most common. Immediate interventional treatment is recommended and routinely requires dual antiplatelet therapy including aspirin and a P2Y12-inhibitor. Therapeutic hypothermia or target temperature management is also recommended in these patients. Cardiogenic shock as well as reduced body temperature impacts platelet reactivity and its medical inhibition. The study aims to quantify aspirin- and P2Y12-mediated platelet inhibition in patients presenting with myocardial infarction and cardiopulmonary resuscitation. Twenty-five resuscitated patients were enrolled in this prospective, observational, non-randomized single-centre study. These patients were compared to 77 matched controls from the ATLANTIS-ACS database of non-resuscitated patients with myocardial infarction. Platelet function testing was performed by light transmittance aggregometry. Aspirin reactivity was monitored by inducing platelet aggregation with collagen and arachidonic acid, respectively. P2Y12 inhibition was recorded by stimulation of platelet aggregation with adenosine diphosphate. To quantify the overall platelet response, thrombin recep...Continue Reading

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Citations

May 6, 2019·Clinical Pharmacology and Therapeutics·Ceren EyiletenMarek Postuła
Dec 19, 2019·Frontiers in Cardiovascular Medicine·Małgorzata OstrowskaJolanta M Siller-Matula
May 15, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Amir LotfiSean van Diepen
Nov 18, 2018·Journal of Clinical Medicine·Florian PrüllerDirk von Lewinski
Jun 9, 2020·European Journal of Clinical Investigation·Gloria M GagerJolanta M Siller-Matula

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NCT02914795

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