Impaired Attentional Set-Shifting Performance after Exposure to 5 cGy of 600 MeV/n 28 Si Particles

Radiation Research
Richard A BrittenChiara La Tessa

Abstract

Astronauts on deep space missions will be required to work more autonomously than on previous missions, and thus their ability to perform executive functions could be critical to mission success. One of the most common measures of executive function in humans is the ability to perform attentional set shifting, which requires contributions from working memory, discrimination, reversal learning, attentional set shifting and attention. Rodent attentional set shifting assays require rats to form an association between the presence of the food reward and an associative cue, which is either the digging media or the scent that is placed in the bowl; by altering the combination of scent and digging media, progressively more complex cognitive processes can be tested. In this study, we have determined the effect that exposure to 5-20 cGy of 600 MeV/n 28Si particles has on the ability of male retired breeder Wistar rats to perform attentional set shifting at three months postirradiation. All doses of Si resulted in a significant impairment in the ability of the rats to perform the first and most simple step of the ATSET assay, the simple discrimination (SD) task. If astronauts were to experience HZE-induced SD impairments, they would be u...Continue Reading

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Citations

May 24, 2019·International Journal of Radiation Biology·Francis A Cucinotta, Eliedonna Cacao
Nov 15, 2019·International Journal of Radiation Biology·Richard A BrittenLarry D Sanford
Aug 28, 2020·Radiation Research·Richard A BrittenLarry D Sanford
Jan 5, 2021·Radiation and Environmental Biophysics·S S SorokinaV A Pikalov
Aug 28, 2021·International Journal of Molecular Sciences·Peter M KleinCharles L Limoli
Oct 1, 2021·Frontiers in Systems Neuroscience·Mona MatarJerry G Myers

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Software Mentioned

ATSET
LET
Prism
GraphPad

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