Impaired auditory evoked potentials and oscillations in frontal and auditory cortex of a schizophrenia mouse model

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Yalda ShahriariJee Hyun Choi

Abstract

In patients with schizophrenia, γ-band (30-70 Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether γ-ASSR deficits are also present in a mouse model of schizophrenia, whose behavioural changes have shown schizophrenia-like endophenotypes. Electroencephalogram in frontal cortex and local field potential in primary auditory cortex were recorded in phospholipase C β1 (PLC-β1) null mice during auditory binaural click trains at different rates (20-50 Hz), and compared with wild-type littermates. In mutant mice, the ASSR power was reduced at all tested rates. The phase locking in frontal cortex was reduced in the β band (20 Hz) but not in the γ band, whereas the phase locking in auditory cortex was reduced in the γ band. The cortico-cortical connectivity between frontal and auditory cortex was significantly reduced in mutant mice. The tested mouse model of schizophrenia showed impaired electrophysiological responses to auditory steady state stimulation, suggesting that it could be useful for preclinical studies of schizophrenia".

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Citations

Mar 3, 2017·Scientific Reports·Hio-Been HanJee Hyun Choi
Jun 26, 2018·International Journal of Radiation Biology·Enis HidisogluPiraye Yargicoglu
Dec 6, 2018·The International Journal of Neuropsychopharmacology·Matthew R HudsonNigel C Jones
May 13, 2020·Journal of Audiology & Otology·Jae-Hun LeeIlyong Park
Aug 1, 2020·Cognitive Neuropsychiatry·Xin-Yang YuRaymond C K Chan
Jun 21, 2020·Annals of Neurology·Seung-Hyun LeeKihoon Han
Sep 10, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Yingzhuo LiLing Qin
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Apr 6, 2021·Frontiers in Systems Neuroscience·Zijie LiLing Qin
Dec 14, 2021·Frontiers in Behavioral Neuroscience·Hea-Jin Kim, Hae-Young Koh

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