PMID: 7016220May 1, 1981Paper

Impaired B-lymphocyte reactivity in patients with Hodgkin's disease and non-Hodgkin-lymphomas

Blut
H RühlG Sieber

Abstract

The generation of immunoglobulin-secreting cells upon stimulation with pokeweed mitogen was studied in patients with Hodgkin's Disease (HD) and non-Hodgkin lymphomas (NHL) using a reverse hemolytic plaque assay. The experiments revealed that the majority of the patients in both groups had greatly diminished responses of their peripheral B-lymphocytes. Whereas in NHL patients an intrinsic B-cell defect is the most likely explanation for the impaired B-cell reactivity, the situation in HD appears to be more complex. In some patients with an active stage of the disease, suppressor cells were found to cause the unresponsiveness: in other patients, an intrinsic B-cell defect as well as a defect of the T helper cells were responsible for the diminished responses. The results further suggest that the immune defect in patients with HD is reversible and can be corrected by therapy.

References

Aug 1, 1975·The Journal of Clinical Investigation·J J TwomeyC C Douglass
Jun 1, 1978·The Journal of Clinical Investigation·S M Hillinger, G P Herzig
Aug 15, 1978·Klinische Wochenschrift·V DiehlJ Deinhardt
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A S Fauci, K R Pratt
Jul 1, 1976·The Journal of Clinical Investigation·F P SiegalR A Good
Jan 24, 1974·The New England Journal of Medicine·R Levy, H S Kaplan
Jan 1, 1972·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·P G Scheurlen
Oct 11, 1974·Nature·S I KatzJ L Turk
Jan 1, 1974·Contemporary Topics in Immunobiology·R K Gershon
Nov 1, 1972·Australian and New Zealand Journal of Medicine·P FiddesM C Rozenberg
Jun 1, 1970·The American Journal of Medicine·T Han, J E Sokal
Nov 4, 1965·The New England Journal of Medicine·E M Hersh, J J Oppenheim
Jan 1, 1956·The American Journal of Medicine·W W SCHIERM H SCHRIFT

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