Impaired baseline regional cerebral perfusion in patients referred for coronary artery bypass

The Journal of Thoracic and Cardiovascular Surgery
Robert MoracaR Alan Hall

Abstract

Cognitive dysfunction and cerebral vascular accidents remain some of the most devastating problems related to cardiac surgery. Despite the major advances in perioperative care and operative technique in coronary artery bypass, this cohort of patients appears to have poor cerebral physiologic reserve. The aim of this study was to describe regional cerebral perfusion of patients with coronary artery disease referred for coronary artery bypass grafting. Eighty-two consecutive patients with coronary artery disease referred for coronary artery bypass grafting were enrolled after providing informed consent in an institutional review board-approved study. Patients with prior cerebral vascular accident, transient ischemic attacks, head trauma, or other neurologic afflictions were excluded from the study. We prospectively measured preoperative regional cerebral perfusion using single photon emission computed tomography (SPECT) imaging of 12 regions. Patients were determined to have an abnormal SPECT if regional cerebral perfusion was less than 2 standard deviations below the mean of age-matched controls. The mean age was 67.5 (range, 34-89) years. The study group comprised 22% women and 78% men with known risk factors for atherosclerosi...Continue Reading

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Citations

Nov 23, 2011·Anesthesia and Analgesia·Brijen JoshiCharles W Hogue
May 8, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Suzan Uysal, David L Reich
Sep 21, 2010·Journal of the Neurological Sciences·Ovidiu BajenaruCristina Tiu
Sep 4, 2008·Anesthesiology Clinics·Kelly GroganCharles W Hogue
Feb 5, 2008·Critical Care Clinics·Charles W HogueJoshua Stearns
Feb 23, 2008·The Annals of Thoracic Surgery·Rebecca Gottesman, Charles W Hogue
Apr 10, 2008·Seminars in Cardiothoracic and Vascular Anesthesia·Gregory W Fischer
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Charles W HogueVictor G Dávila-Román
Sep 30, 2009·Anesthesiology·Don PoldermansLee A Fleisher
Dec 14, 2016·Proceedings. Mathematical, Physical, and Engineering Sciences·E K LenziL R Evangelista
Aug 19, 2010·Anaesthesia and Intensive Care·S D GalvinP N Ainslie
Jan 10, 2018·Anaesthesia·R HoodC W Hogue
Oct 19, 2017·The Journal of Thoracic and Cardiovascular Surgery·Daijiro HoriCharles W Hogue

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