Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Christopher PittengerRiccardo Brambilla

Abstract

The striatum has a well documented role in procedural learning and memory. However, the synaptic and molecular mechanisms of acquisition and storage of this form of memory remain poorly understood. We examined procedural memory and plasticity in transgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. In these transgenic mice, corticostriatal long-term potentiation and depression are abolished, indicating that CREB function is essential for bidirectional long-term synaptic plasticity in this structure. Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory, including footshock avoidance learning and "response" learning in the cross maze. These findings implicate transcriptional regulation by CREB family transcription factors in striatum-dependent information processing and provide the first clear correlation between procedural learning and memory and synaptic plasticity at the corticostriatal synapse.

Citations

Sep 29, 2011·Molecular Neurobiology·Angel Barco, Hélène Marie
Sep 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher Pittenger, Ronald S Duman
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anni S LeeChristopher Pittenger
Aug 12, 2009·Cerebral Cortex·Cameron S McPhersonAndrew J Lawrence
Dec 7, 2010·ILAR Journal·Jose L Pena, William M DeBello
Mar 2, 2010·Learning & Memory·Mazen A KheirbekXiaoxi Zhuang
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Grant S Nichols, William M DeBello
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mazen A KheirbekXiaoxi Zhuang
Jul 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Susan M FergusonJohn F Neumaier
Jan 7, 2014·Biological Psychiatry·Eleanor H SimpsonChristoph Kellendonk
Feb 26, 2016·Frontiers in Nutrition·Heike MünzbergHans-Rudolf Berthoud
Sep 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Christiane SchreiweisAnn M Graybiel
Jun 28, 2011·Progress in Neurobiology·Michael W Shiflett, Bernard W Balleine
Nov 17, 2009·Brain and Language·Stephanie A White
Aug 25, 2009·Journal of Neuroscience Methods·Alessandro PapaleRiccardo Brambilla
Jan 10, 2009·Behavioural Brain Research·Mark G Packard
Nov 3, 2007·Neurobiology of Learning and Memory·Jennifer J BrightwellPaul J Colombo
May 5, 2007·Neurobiology of Aging·Yves PorteNicole Mons
Apr 17, 2007·Annals of the New York Academy of Sciences·Rui M Costa
Sep 11, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Kim T Blackwell, Joanna Jedrzejewska-Szmek
Jan 10, 2013·The European Journal of Neuroscience·Jennifer J QuinnJane R Taylor
Jul 6, 2013·Neurobiology of Learning and Memory·Milica CerovicRiccardo Brambilla
Dec 15, 2010·Behavioural Brain Research·Michael W Shiflett, Bernard W Balleine
Dec 8, 2011·Physiology & Behavior·Wayne R HawleyGary P Dohanich
Jan 26, 2011·Brain Research·Ruey-Kuang ChengWarren H Meck
Apr 3, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zhi-Yan ShanLian-Hong Jin
Apr 15, 2020·International Journal of Molecular Sciences·Inwoo Hwang, Jee-Yin Ahn

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