PMID: 2504996Oct 1, 1989Paper

Impaired bowel motility following small intestinal transplantation

The Journal of Surgical Research
D W VaneA Hurwitz

Abstract

Little information is available concerning motility following bowel transplantation and the appropriate timing of offering enteral feedings. Eight Lewis rats (300 g) underwent small bowel transplant as described by R. P. Harmel, Jr., and H. Stanley (J. Pediatr. Surg. 21:214, 1986). Silver oxide electrodes were placed in the native proximal ileum and in the distal segment of the homograft. Four control rats underwent laparotomy and placement of silver oxide electrodes in the jejunum and proximal ileum. Leads were brought out through a stab wound and the abdominal incision was closed. The electrodes were connected to a continuous recorder. Basal electrical rhythm (BER) was recorded periodically and was evaluated daily as the average of three readings per animal per day. Homograft electrical activity was not observed until at least 40 hr post-transplant and never attained the level of BER of the native intestine (P less than 0.05). Myoelectric complex potentials were not observed in the transplanted rats until post-operative day 11. These data suggest that basal electrical activity is significantly impaired following bowel transplantation. This study indicates that intestinal activity can be monitored for extended periods of time ...Continue Reading

References

Jul 1, 1989·Journal of Pediatric Surgery·D H TeitelbaumR P Harmel
Jul 1, 1988·The Journal of Surgical Research·D E MatthewsJ L Grosfeld
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·Z CohenB Langer
May 1, 1985·Transplantation·R WassefB Langer
Jun 1, 1985·The Journal of Surgical Research·T J PritchardR L Kirkman
Dec 1, 1985·Journal of Pediatric Surgery·F M GuttmanL Gibbons
Jul 1, 1984·The Journal of Surgical Research·T R BilliarW H Schraut
Dec 1, 1984·Journal of Pediatric Surgery·A CooperM M Ziegler

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Citations

Jun 1, 1994·Digestive Diseases and Sciences·H PernthalerR Margreiter
Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·R SchlemmingerA Schafmayer
Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·R SchlemmingerA Schafmayer
Sep 24, 1998·Transplantation Proceedings·A M MinioliA Bakonyi Neto
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·R W de BruinR L Marquet
Jan 1, 1992·Langenbecks Archiv für Chirurgie·H PernthalerR Margreiter

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