Impaired capacity for stimulated fibrinolysis in primary hypertension is restored by antihypertensive therapy

Hypertension
Wilhelm RidderstråleT Hrafnkelsdottir

Abstract

The increased risk for myocardial infarction and ischemic stroke in primary hypertension suggests that the condition is associated with prothrombotic mechanisms. We have shown that patients with hypertension have an impaired capacity for acute endothelial tissue-type plasminogen activator (t-PA) release, an important local protective response to prevent formation of intravascular thrombi. The aim of the present study was to investigate whether this impairment could be restored by the lowering of blood pressure. The capacity for acute t-PA release in response to intraarterial infusion of substance P at 8 pmol/min was investigated in a perfused-forearm study in 20 hypertensive patients (12 men and 8 women). Studies were performed when patients were untreated and after 8 weeks of randomized treatment with lisinopril or felodipine that lowered blood pressure by 26/10 and 24/12 mm Hg, respectively. The t-PA release response increased significantly with treatment (ANOVA, P=0.0001), with a similar effect in the 2 treatment groups. The peak release of t-PA increased from 257 (58) to 445 (77) ng/min x L/tissue(-1) (t test, P=0.02). Also, treatment shortened the average time to peak secretion from 6.7 (1.4) to 2.7 (0.3) min (t test, P=0....Continue Reading

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Citations

May 27, 2011·Journal of Thrombosis and Thrombolysis·Wilhelm RidderstråleThórdís J Hrafnkelsdóttir
Dec 12, 2012·Journal of Thrombosis and Thrombolysis·Pia LarssonSverker Jern
Feb 18, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tetsuya Matsumoto, Minoru Horie
Dec 10, 2008·Endothelium : Journal of Endothelial Cell Research·N BerghS Jern
Sep 29, 2007·Trends in Molecular Medicine·Hubert TsuiH-Michael Dosch
Aug 21, 2007·Lancet·Franz H MesserliEberhard Ritz
Apr 4, 2007·Journal of Thrombosis and Haemostasis : JTH·K JoodT Hrafnkelsdóttir
Apr 10, 2014·Thrombosis Research·Leandi LammertynRudolph Schutte
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Jan 1, 2009·Biochemical and Biophysical Research Communications·Erik UlfhammerSverker Jern
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Jan 17, 2017·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Marzena Wojewodzka-ZelezniakowiczEwa Chabielska
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Jul 8, 2010·Hypertension·Tetsuya MatsumotoUNKNOWN Shiga Plasminogen Activator in Coronary Circulation (SPAIC) Investigators
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Feb 5, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Annabella Braschi
Sep 19, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jérémy BellienRobinson Joannidès
Aug 25, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Jiyuan PiaoYoungsook Son

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