Abstract
Being a secreted protein, periostin is a multifunctional matricellular glycoprotein. In vitro, periostin has the ability to promote the proliferation and migration of fibroblasts. Previously, it was demonstrated that periostin is mainly produced by cancer-associated fibroblasts or tumor stromal cells. In the present study, we show that periostin regulates capsule formation in a positive manner and inhibits tumor growth. Consistent with a previous finding, several tumor cell lines did not exhibit expression of periostin in vitro or in vivo; and the growth of tumors that had been allografted into periostin -/- mice was significantly accelerated compared with that of the same kind of tumors grafted into periostin +/+ mice. Immunostaining and biochemical analyses revealed that mature collagen was detected abundantly in the capsules and interstitium of the wild-type-grafted tumors but not in those of the periostin -/- grafted tumors. Moreover, the number of activated tumor stromal cells was decreased significantly in the periostin -/- grafted tumors. Our studies suggest that host-derived periostin negatively regulates tumor growth by promoting capsule formation and by mediating changes in the deposition and organization of the tumor...Continue Reading
References
Aug 1, 1997·Nature Biotechnology·G HelmlingerR K Jain
May 11, 2002·Journal of Biomechanical Engineering·S R Lubkin, T Jackson
Apr 15, 2004·Molecular and Cellular Biology·Rong ShaoXiao-Fan Wang
Apr 20, 2004·Cancer Cell·Shideng BaoXiao-Fan Wang
Sep 11, 2004·Biochemical and Biophysical Research Communications·Rong Shao, Xing Guo
Feb 25, 2006·Biochemical and Biophysical Research Communications·Isao KiiAkira Kudo
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Go TakayamaKenji Izuhara
Jan 18, 2007·Journal of Cellular Biochemistry·Russell A NorrisRoger R Markwald
Nov 3, 2007·Cancer Research·Elisabeth M ZeisbergRaghu Kalluri
Dec 22, 2007·International Journal of Oncology·Chul Jang KimHirokazu Inoue
Apr 30, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshinao KikuchiMasashi Fukayama
Citations
Aug 13, 2011·Cellular and Molecular Life Sciences : CMLS·Akira Kudo
Jul 28, 2009·Journal of Biochemistry·Issei TakayamaAkira Kudo
Aug 23, 2012·PloS One·Lingli YangIchiro Katayama
Oct 23, 2013·Cellular and Molecular Life Sciences : CMLS·Simon J ConwayAkira Kudo
Jan 15, 2014·The American Journal of Pathology·Yoshinao KikuchiTakeshi G Kashima
Dec 14, 2011·Nature·Ilaria MalanchiJoerg Huelsken
Dec 9, 2015·Hypertension·Yoshiaki TaniyamaRyuichi Morishita
Jan 1, 2009·International Journal of Cancer. Journal International Du Cancer·Nuray ErinGary A Clawson
Aug 21, 2009·The American Journal of Clinical Nutrition·Joyce C McCann, Bruce N Ames
Apr 8, 2010·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·H E GruberE N Hanley
Aug 23, 2018·Oncotarget·Toshimasa OkazakiKennichi Satoh
Jun 6, 2018·Scientific Reports·Fumiko NakazekiKoh Ono
Jul 27, 2018·Scientific Reports·Ryoko InakiKazuto Hoshi
Jun 2, 2018·BioMed Research International·Hahn-Sol BaeJi-Ung Park
Mar 1, 2014·The Journal of Investigative Dermatology·Lingli YangIchiro Katayama
Jul 30, 2009·Journal of Cell Science·Angela Moncada-PazosSantiago Cal
Jul 19, 2015·Journal of Cell Science·Eva Sonnenberg-RiethmacherDieter Riethmacher
Jan 6, 2009·The Journal of Hand Surgery·Barbara ShihArdeshir Bayat