Impaired capsule formation of tumors in periostin-null mice

Biochemical and Biophysical Research Communications
Masashi Shimazaki, Akira Kudo

Abstract

Being a secreted protein, periostin is a multifunctional matricellular glycoprotein. In vitro, periostin has the ability to promote the proliferation and migration of fibroblasts. Previously, it was demonstrated that periostin is mainly produced by cancer-associated fibroblasts or tumor stromal cells. In the present study, we show that periostin regulates capsule formation in a positive manner and inhibits tumor growth. Consistent with a previous finding, several tumor cell lines did not exhibit expression of periostin in vitro or in vivo; and the growth of tumors that had been allografted into periostin -/- mice was significantly accelerated compared with that of the same kind of tumors grafted into periostin +/+ mice. Immunostaining and biochemical analyses revealed that mature collagen was detected abundantly in the capsules and interstitium of the wild-type-grafted tumors but not in those of the periostin -/- grafted tumors. Moreover, the number of activated tumor stromal cells was decreased significantly in the periostin -/- grafted tumors. Our studies suggest that host-derived periostin negatively regulates tumor growth by promoting capsule formation and by mediating changes in the deposition and organization of the tumor...Continue Reading

References

Aug 1, 1997·Nature Biotechnology·G HelmlingerR K Jain
May 11, 2002·Journal of Biomechanical Engineering·S R Lubkin, T Jackson
Feb 25, 2006·Biochemical and Biophysical Research Communications·Isao KiiAkira Kudo
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Go TakayamaKenji Izuhara
Jan 18, 2007·Journal of Cellular Biochemistry·Russell A NorrisRoger R Markwald
Dec 22, 2007·International Journal of Oncology·Chul Jang KimHirokazu Inoue
Apr 30, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yoshinao KikuchiMasashi Fukayama

❮ Previous
Next ❯

Citations

Aug 13, 2011·Cellular and Molecular Life Sciences : CMLS·Akira Kudo
Oct 23, 2013·Cellular and Molecular Life Sciences : CMLS·Simon J ConwayAkira Kudo
Jan 1, 2009·International Journal of Cancer. Journal International Du Cancer·Nuray ErinGary A Clawson
Aug 21, 2009·The American Journal of Clinical Nutrition·Joyce C McCann, Bruce N Ames
Apr 8, 2010·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·H E GruberE N Hanley
Jun 6, 2018·Scientific Reports·Fumiko NakazekiKoh Ono
Jun 2, 2018·BioMed Research International·Hahn-Sol BaeJi-Ung Park
Mar 1, 2014·The Journal of Investigative Dermatology·Lingli YangIchiro Katayama
Jul 19, 2015·Journal of Cell Science·Eva Sonnenberg-RiethmacherDieter Riethmacher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.