Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice.

Molecular and Cellular Biology
Xiao-Jun DuJörg Heierhorst

Abstract

Ca(2+) signaling plays a central role in cardiac contractility and adaptation to increased hemodynamic demand. We have generated mice with a targeted deletion of the S100A1 gene coding for the major cardiac isoform of the large multigenic S100 family of EF hand Ca(2+)-binding proteins. S100A1(-/-) mice have normal cardiac function under baseline conditions but have significantly reduced contraction rate and relaxation rate responses to beta-adrenergic stimulation that are associated with a reduced Ca(2+) sensitivity. In S100A1(-/-) mice, basal left-ventricular contractility deteriorated following 3-week pressure overload by thoracic aorta constriction despite a normal adaptive hypertrophy. Surprisingly, heterozygotes also had an impaired response to acute beta-adrenergic stimulation but maintained normal contractility in response to chronic pressure overload that coincided with S100A1 upregulation to wild-type levels. In contrast to other genetic models with impaired cardiac contractility, loss of S100A1 did not lead to cardiac hypertrophy or dilation in aged mice. The data demonstrate that high S100A1 protein levels are essential for the cardiac reserve and adaptation to acute and chronic hemodynamic stress in vivo.

References

Sep 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·H A RockmanK R Chien
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Jan 27, 1995·Cell·D E Clapham
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·W C ProbstK R Weiss
Apr 18, 1996·Nature·J HeierhorstB E Kemp
Feb 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M GarbugliaR Donato
Apr 1, 1996·Trends in Biochemical Sciences·B W Schäfer, C W Heizmann
Oct 11, 1996·Biochimica Et Biophysica Acta·A RemppisC W Heizmann
Nov 21, 1996·European Journal of Pharmacology·K NakataniT Tanaka
Mar 6, 1997·Nature·K ChawengsaksophakF Beck
Oct 28, 1998·The Journal of Clinical Investigation·J N TsoporisT G Parker
Jan 27, 1999·Biochimica Et Biophysica Acta·K RidingerB W Schäfer
Nov 24, 1999·The Biochemical Journal·J HeierhorstB E Kemp
Dec 11, 1999·Journal of Molecular and Cellular Cardiology·D J MilnerY Capetanaki
Mar 16, 2000·The New England Journal of Medicine·M C DalakasL G Goldfarb
Jun 9, 2000·Annual Review of Physiology·H Kiriazis, E G Kranias
Aug 5, 2000·Biochemical and Biophysical Research Communications·R KiewitzC W Heizmann
Dec 8, 2000·Biochimica Et Biophysica Acta·R KiewitzC W Heizmann
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·P MostA Remppis
Apr 1, 1994·The Plant Cell·P. H. QuailG. C. Whitelam

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Citations

Mar 27, 2010·Acta Neuropathologica·Jennifer A MorralArnulf H Koeppen
Jul 21, 2010·Journal of Cardiovascular Translational Research·David RohdePatrick Most
Jan 15, 2004·Experimental Cell Research·Stéphane DedieuJean-Jacques Brustis
Apr 13, 2013·Cell Death and Differentiation·Y Y LeeH Puthalakath
Feb 18, 2012·Gene Therapy·J Ritterhoff, P Most
Oct 24, 2012·Nature Reviews. Cardiology·Changwon KhoRoger J Hajjar
Apr 18, 2007·Molecular and Cellular Biology·Melanie BoerriesCora-Ann Schoenenberger
Mar 18, 2003·Molecular and Cellular Biology·Josie A R HobbsNancy Hogg
Jan 14, 2003·Annual Review of Physiology·N Frey, E N Olson
Jun 21, 2008·Circulation Research·Leif Erik VingeWalter J Koch
Dec 7, 2011·Circulation·Koichi ShimizuKevin Croce
Dec 22, 2010·Circulation·Izhak Kehat, Jeffery D Molkentin
Oct 27, 2010·PLoS Genetics·Sabine JuradoJörg Heierhorst
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mitsuhiko Ikura, James B Ames
Jul 22, 2011·Science Translational Medicine·Sven T PlegerPatrick Most
Apr 7, 2010·Journal of Biomedicine & Biotechnology·Mirko VölkersPatrick Most
Mar 26, 2011·Expert Opinion on Biological Therapy·Rabea HinkelChristian Kupatt
Aug 20, 2014·Journal of Molecular Biology·Filip Van Petegem
May 24, 2011·The Canadian Journal of Cardiology·Kleopatra RaptiRoger J Hajjar
Oct 12, 2010·Progress in Biophysics and Molecular Biology·Dong Woo SongDo Han Kim
Jul 26, 2011·Science China. Life Sciences·Lynn Kimlicka, Filip Van Petegem
Aug 25, 2010·Journal of Molecular and Cellular Cardiology·David RohdePatrick Most
Jun 23, 2009·Journal of Molecular and Cellular Cardiology·Carolin KrausPatrick Most
May 20, 2009·Journal of Molecular Biology·Nathan T WrightDavid J Weber
Nov 12, 2009·BioFactors·Ilse VandecaetsbeekPeter Vangheluwe
Mar 2, 2005·Pharmacology & Therapeutics·Masahiko Hoshijima
Sep 1, 2004·Biochemical and Biophysical Research Communications·Ingo MarenholzGünter Fritz
Jun 14, 2003·Biochemical and Biophysical Research Communications·Roland KiewitzClaus W Heizmann
Sep 1, 2004·Expert Opinion on Biological Therapy·Jacob N SchroderWalter J Koch
Dec 4, 2004·The Journal of Clinical Investigation·Patrick MostWalter J Koch
Nov 16, 2010·Archives of Cardiovascular Diseases·Mario T Njeim, Roger J Hajjar
Aug 20, 2011·Journal of the American College of Cardiology·Henriette BrinksPatrick Most
Jan 6, 2009·Biochimica Et Biophysica Acta·Estelle LeclercClaus W Heizmann
Oct 19, 2006·Biochimica Et Biophysica Acta·Gabriele E AckermannClaus W Heizmann
Oct 30, 2007·Biochemical and Biophysical Research Communications·Marcus C Schaub, Claus W Heizmann
Nov 4, 2004·Journal of Molecular and Cellular Cardiology·Xiao-Jun DuRobert M Graham

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