Impaired cardiac mitochondrial oxidative phosphorylation and enhanced mitochondrial oxidative stress in feline hypertrophic cardiomyopathy

American Journal of Physiology. Heart and Circulatory Physiology
Liselotte Bruun ChristiansenTakashi Yokota

Abstract

Mitochondrial dysfunction and oxidative stress are important players in the development of various cardiovascular diseases, but their roles in hypertrophic cardiomyopathy (HCM) remain unknown. We examined whether mitochondrial oxidative phosphorylation (OXPHOS) capacity was impaired with enhanced mitochondrial oxidative stress in HCM. Cardiac and skeletal muscles were obtained from 9 domestic cats with spontaneously occurring HCM with preserved left ventricular systolic function and from 15 age-matched control cats. Mitochondrial OXPHOS capacities with nonfatty acid and fatty acid substrates in permeabilized fibers and isolated mitochondria were assessed using high-resolution respirometry. ROS release originating from isolated mitochondria was assessed by spectrofluorometry. Thiobarbituric acid-reactive substances were also measured as a marker of oxidative damage. Mitochondrial ADP-stimulated state 3 respiration with complex I-linked nonfatty acid substrates and with fatty acid substrates, respectively, was significantly lower in the hearts of HCM cats compared with control cats. Mitochondrial ROS release during state 3 with complex I-linked substrates and thiobarbituric acid-reactive substances in the heart were significantly...Continue Reading

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Citations

Jan 19, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·L B ChristiansenJ Koch
Jun 19, 2019·FEBS Letters·Vasco SequeiraChristoph Maack
Apr 16, 2020·Journal of the American Heart Association·Rahana Y ParbhudayalJolanda van der Velden
Jun 13, 2020·Journal of Clinical Medicine·Maria LombardiPaolo G Camici
Oct 30, 2016·The International Journal of Biological Markers·Yun WangJuan Zhang
Jan 1, 2020·Biochemistry and Biophysics Reports·Satoshi MaekawaShintaro Kinugawa
Jan 31, 2021·Communications Biology·Takaaki FurihataShintaro Kinugawa
Sep 2, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lorenzo SantiniRaffaele Coppini
May 7, 2021·Scientific Reports·Jacob Marthinsen SeefeldtHans Erik Bøtker
Jul 24, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·M B T BachJ Koch

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