Impaired CD8 T cell antiviral immunity following acute spinal cord injury

Journal of Neuroinflammation
Diana M NordenJiu Jiang

Abstract

Spinal cord injury (SCI) disrupts essential neuroimmune communication, leading to severe immune depression. Previous studies confirmed immune dysfunction in mice with chronic SCI and following high thoracic level injury where sympathetic innervation of the spleen is disrupted. Here, we induced a mid-thoracic injury where integrity of the sympathetic response is maintained and investigated the antiviral T cell response to influenza virus after acute SCI. One week following a contusion SCI at thoracic level T9, mice were infected intranasally with influenza virus. Profiles of immune cell populations were analyzed before infection, and virus-specific CD8 T cell response was analyzed 7 days post-infection. Following intranasal infection, injured mice had prolonged recovery and significant weight loss. Importantly, expansion and effector functions of virus-specific CD8 T cells were decreased in injured mice. The compromised CD8 T cell response was associated with inflammation and stress responses initiated after injury. Regulatory mechanisms, including increased regulatory T cells (Tregs) and upregulated PD-1/PD-L1, were induced following SCI. Furthermore, we show that increased corticosterone (CORT) levels can inhibit CD8 T cells a...Continue Reading

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Citations

Aug 4, 2019·International Journal of Molecular Sciences·James HongMichael G Fehlings
Oct 31, 2020·PloS One·Antigona UlndreajMichael G Fehlings
Oct 28, 2020·Annals of the New York Academy of Sciences·Karim SahbaniHesham A Tawfeek
Apr 15, 2021·International Immunology·Masaki Ueno

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Methods Mentioned

BETA
FACS
flow cytometry

Software Mentioned

FlowJo
GolgiStop
SPSS

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