Impaired cerebrovascular reactivity in obstructive sleep apnea: a case-control study

Sleep Medicine
Laura B PonsaingPoul Jennum

Abstract

Obstructive sleep apnea (OSA) is an independent risk factor for stroke. Little is known about the cerebrovascular hemodynamic changes during apnea. Hypercapnia occurs in apneas and hypopneas, and a reduced cerebral vasodilatory response to CO2 could compromise the cerebral blood flow (CBF). Therefore, we aimed to evaluate whether the apnea-hypopnea index (AHI) affected the cerebrovascular response to CO2. A total of 11 patients with OSA were compared to 16 controls. We assessed the cerebrovascular responses with arterial spin labeling (ASL) and blood oxygen level-dependent (BOLD) magnetic resonance imaging during hypercapnia or breath-holding tasks. The CBF response to CO2 was impaired with increasing AHI (average CBF: p = 0.018; gray matter: p = 0.038; white matter: p = 0.045), that is, increased OSA severity. When comparing the OSA patients to the control subjects, the OSA patients had a significantly reduced CO2 response of the white matter CBF (p = 0.04). However, the BOLD response to CO2 and the breath-holding task did not show any significant differences between OSA patients and control subjects. The cerebrovascular CO2 reactivity, measured by the CBF, was impaired with increasing AHI, that is, OSA severity. These finding...Continue Reading

Citations

Nov 13, 2018·Current Opinion in Neurology·Clare L Fraser
Jul 3, 2019·Experimental Physiology·Shigehiko OgohTadayoshi Miyamoto
Mar 29, 2019·Journal of Applied Physiology·Shigehiko Ogoh
Dec 19, 2019·Current Sleep Medicine Reports·H Lee LauAlberto R Ramos
Feb 5, 2021·Frontiers in Physiology·Joana PintoPatrícia Figueiredo
Mar 16, 2021·Frontiers in Physiology·Emilie SleightMichael J Thrippleton
Sep 4, 2021·Sleep & Breathing = Schlaf & Atmung·Sofie Amalie SimonsenHelle K Iversen

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