Impaired Circadian Photoentrainment in Opn5-Null Mice

IScience
Wataru OtaTakashi Yoshimura

Abstract

The master circadian pacemaker in mammals resides in the hypothalamic suprachiasmatic nuclei (SCN) and is synchronized to ambient light/dark cycles (i.e., photoentrainment). Melanopsin (Opn4) and classical rod-cone photoreceptors are believed to provide all the photic input necessary for circadian photoentrainment. Although the UVA-sensitive photopigment Opn5 is known to be expressed in retinal ganglion cells, its physiological role remains unclear and a potential role for Opn5 in the photoentrainment of the master clock has not been addressed. Here we report impaired photoentrainment and phase shifting to UVA light in Opn5-null mice. However, triple-knockout mice lacking all known functional circadian photoreceptors (i.e., rods, cones, and melanopsin) failed to entrain to UVA-light/dark cycles, despite the presence of Opn5, demonstrating that Opn5 alone is not sufficient for photoentrainment of the SCN clock. Since Opn5 is involved in the regulation of the retinal circadian clock, disrupted retinal function may cause impaired circadian photoentrainment in Opn5-null mice.

Citations

Jun 17, 2020·Investigative Ophthalmology & Visual Science·Nicolás M DíazEthan D Buhr
Jan 13, 2019·Biology·Pingkalai R SenthilanCharlotte Helfrich-Förster
Mar 8, 2019·Scientific Reports·Wataru OtaTakashi Yoshimura
Mar 11, 2020·Biophysics Reviews·Takahiro Yamashita
Apr 3, 2019·Nature Cell Biology·Minh-Thanh T NguyenRichard A Lang
Sep 22, 2020·Journal of Photochemistry and Photobiology. B, Biology·Gabriel E BertolesiSarah McFarlane
Mar 27, 2021·Journal of Biological Rhythms·Brian A UptonRichard A Lang
May 26, 2021·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyan JiangKazuo Tsubota
Nov 8, 2021·The Journal of Comparative Neurology·Shane P D'SouzaRichard A Lang

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Methods Mentioned

BETA
genotyping

Software Mentioned

GraphPad Prism

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