Impaired cognition is related to microstructural integrity in relapsing remitting multiple sclerosis.

Annals of Clinical and Translational Neurology
Lin ZhaoAlexander Y Lau

Abstract

Cognitive impairment is common in multiple sclerosis (MS). However, the relationship between cognitive deficits and microstructural abnormalities in Chinese MS patients remains unclear. We aimed to investigate the importance of microstructural abnormalities and the associations with cognitive impairment in Chinese MS patients. Three-dimensional T1-weighted magnetic resonance imaging (MRI) scans were obtained from 36 relapsing remitting MS patients. Diffusion tensor imaging (DTI) scans were acquired for 29 (81%) patients. Cognitive impairment was assessed using a comprehensive neuropsychological battery. Patients were classified into cognitively impaired (CI) group and cognitively preserved (CP) group. Using volBrain and FSL software, we assessed white matter lesion burden, white matter (WM) and gray matter (GM) volumetric as well as microstructural diffusivity. MRI variables explaining cognitive impairment were analyzed. Fifteen (42%) patients were classified as CI. Verbal learning and memory was the most commonly impaired domain (n = 16, 44%). CI patients had lower mean skeleton fractional anisotropy (FA) value than CP patients (275.45 vs. 283.61 × 10-3 , P = 0.023). The final predicting model including demographic variables a...Continue Reading

References

Feb 1, 1991·Psychological Medicine·M A RonE K Warrington
Jul 1, 1987·Journal of Clinical Psychology·J D Corrigan, N S Hinkeldey
Nov 24, 1999·Journal of the International Neuropsychological Society : JINS·A S Chan, M W Poon
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Aug 21, 2002·Journal of Clinical and Experimental Neuropsychology·Tatia LeeChetwyn Chan
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Feb 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·U NocentiniC Caltagirone
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Jul 12, 2007·Multiple Sclerosis : Clinical and Laboratory Research·B I GlanzH L Weiner
Aug 11, 2007·NeuroImage·Dimitri Van De VilleMichael Unser
Oct 28, 2008·Brain : a Journal of Neurology·R A DineenD P Auer
Dec 11, 2008·Human Brain Mapping·Sarlota MesarosMassimo Filippi
Mar 30, 2011·Neurology·M S A DeloireB Brochet
Oct 16, 2012·Brain : a Journal of Neurology·Massimiliano CalabresePaolo Gallo
Apr 5, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Richard A Armstrong
Nov 25, 2014·Cellular and Molecular Life Sciences : CMLS·Markus KippOmid Nikoubashman
Feb 11, 2015·Lancet Neurology·Maria A RoccaUNKNOWN MAGNIMS Study Group
Jun 26, 2015·Applied Neuropsychology. Adult·Douglas M WhitesideBrad Roper
Jul 26, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Marita DaamsFrederik Barkhof
Oct 21, 2015·NeuroImage·Jesper L R Andersson, Stamatios N Sotiropoulos
Jan 7, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Kim A MeijerOlga Ciccarelli
Feb 3, 2016·Human Brain Mapping·Paolo PreziosaUNKNOWN MAGNIMS Study Group
Aug 12, 2016·Frontiers in Neuroinformatics·José V Manjón, Pierrick Coupé
Apr 7, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Gavin GiovannoniEva Havrdová
May 13, 2017·Journal of Neuroimmunology·Guiyou LiuJunwei Hao
Jul 18, 2017·Frontiers in Neuroscience·Jeroen Van Schependom, Guy Nagels
Oct 21, 2017·Brain : a Journal of Neurology·Maria A RoccaMassimo Filippi
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Mar 27, 2018·Multiple Sclerosis and Related Disorders·G LuM H Barnett
Dec 28, 2018·Brain and Behavior·Marcin KolasaMarja-Liisa Sumelahti

❮ Previous
Next ❯

Software Mentioned

TBSS
FMRIB58
FLIRT
FNIRT
FMRIB Software Library ( FSL )
Tract Based Spatial Statistic ( TBSS )
LST
volBrain
Eddy
FSL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.