PMID: 8472272Feb 1, 1993Paper

Impaired contraction and relaxation in skin resistance arteries from patients with congestive heart failure

Cardiovascular Research
J A AngusG L Jennings

Abstract

The aim was to determine the pharmacological reactivity of human small resistance arteries in patients with cardiac failure. Small arteries (< 300 microns internal diameter) were removed from gluteal skin biopsy specimens and mounted in a double myograph for isometric force recording. Arteries from six patients with congestive heart failure contracted to only 65% of the maximum response recorded in nine arteries from normal volunteers when activated by potassium chloride (124 mM), noradrenaline (1 microM), or both. The lesser contraction in congestive heart failure vessels with no significant shift in sensitivity (EC50) was also observed in concentration-response studies with noradrenaline, angiotensin I, and angiotensin II. The concentration-contraction curves for serotonin showed only 40% of the maximum contractility to K+ in normal arteries, and this ratio was similar in congestive heart failure arteries. Normal arteries precontracted with noradrenaline (1 microM) relaxed in response to sodium nitroprusside, calcitonin gene related peptide, and the endothelium dependent agonist acetylcholine; in congestive heart failure vessels there was a marked loss of the relaxation response only to acetylcholine. These results suggest th...Continue Reading

Citations

Sep 1, 1994·Basic Research in Cardiology·I RubinsteinI H Zucker
Oct 6, 1998·European Journal of Pharmacology·D L PriorJ P Chin-Dusting
Dec 16, 1998·European Journal of Pharmacology·A BergdahlL Edvinsson
Apr 28, 2001·Journal of Pharmacological and Toxicological Methods·J A Angus, C E Wright
Sep 1, 1994·Clinical and Experimental Pharmacology & Physiology·D M KayeJ A Angus
Oct 3, 1998·Microvascular Research·A ColantuoniS Bertuglia
Dec 23, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Alexander NapPieter A van Zwieten
Sep 29, 1998·Clinical and Experimental Pharmacology & Physiology·J P Chin-Dusting, D M Kaye
May 1, 1997·Clinical and Experimental Pharmacology & Physiology·J A Angus
Aug 1, 1996·Clinical and Experimental Pharmacology & Physiology·J A Angus
Jun 8, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adrian GerickeAndreas Patzak
Jun 1, 1997·Journal of Cardiovascular Pharmacology·F R StassenJ G De Mey
Jun 5, 1998·The American Journal of Physiology·N StephensA M Heagerty

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