Impaired cough suppression in chronic refractory cough

The European Respiratory Journal
Peter S P ChoSurinder S Birring

Abstract

Functional brain imaging in individuals with chronic cough demonstrates reduced activation in cortical regions associated with voluntary cough suppression. Little is known about the ability of patients with chronic cough to suppress cough. This study aimed to compare the ability to voluntarily suppress cough during inhaled capsaicin challenge in participants with chronic refractory cough with that in healthy controls. In addition, this study aimed to assess the repeatability of capsaicin challenge test with voluntary cough suppression.Participants with chronic refractory cough and healthy controls underwent inhaled capsaicin challenge tests while attempting to suppress their cough responses. After 5 days, either a conventional capsaicin challenge test with no cough suppression attempt, or a repeat test with an attempt at cough suppression was performed. Threshold capsaicin concentrations required to elicit one, two and five coughs were calculated by interpolation. Objective 24-h cough frequency was measured in individuals with chronic refractory cough.Healthy controls were able to suppress capsaicin-evoked cough while participants with chronic refractory cough were not. Geometric mean±sd capsaicin dose thresholds for five cough...Continue Reading

References

May 1, 1996·Respiratory Medicine·F O'ConnellR W Fuller
Aug 13, 1998·Archives of Internal Medicine·C L FrenchC J Krikorian
Dec 7, 2000·The New England Journal of Medicine·R S Irwin, J M Madison
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Mar 27, 2003·Pulmonary Pharmacology & Therapeutics·Peter V Dicpinigaitis
Mar 9, 2004·The Journal of Physiology·Brendan J CanningBradley J Undem
Jan 1, 1950·Cancer·W J YOUDEN
Feb 12, 2005·Chest·Benjamin PrudonIan D Pavord
May 13, 2005·Chest·Rubaiyat A HaquePeter J Barnes
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Nov 4, 2005·Respiratory Medicine·Surinder S BirringIan D Pavord
May 24, 2006·Archives of Internal Medicine·Robert L SpitzerBernd Löwe
Jun 20, 2006·Cough·Lorcan P A McGarveyJoseph MacMahon
Aug 29, 2006·Thorax·A H MoriceUNKNOWN British Thoracic Society Cough Guideline Group
Nov 24, 2006·American Journal of Respiratory and Critical Care Medicine·Alyn H MoriceRachel Thompson
Dec 15, 2006·Chest·Peter V DicpinigaitisGisela Banauch
Jun 2, 2007·The European Respiratory Journal·A H MoriceUNKNOWN European Respiratory Society (ERS)
Dec 15, 2010·American Journal of Respiratory and Critical Care Medicine·Surinder S Birring
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stuart B MazzoneMichael J Farrell
Apr 12, 2012·Journal of Applied Physiology·Karen W HeglandPaul W Davenport
Oct 8, 2013·American Journal of Respiratory and Critical Care Medicine·Jennifer LeechMichael J Farrell
Aug 19, 2014·Respiratory Medicine·Teet PulleritsEva Millqvist
Feb 7, 2015·The European Respiratory Journal·Woo-Jung SongAlyn H Morice
Dec 17, 2015·BMJ : British Medical Journal·Peter G Gibson, Anne E Vertigan
Jun 20, 2018·The Lancet. Respiratory Medicine·Stuart B MazzoneLorcan McGarvey

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Citations

May 3, 2019·The European Respiratory Journal·Stuart B Mazzone
Jun 6, 2019·The European Respiratory Journal·Richard D Turner, Surinder S Birring
Jan 9, 2020·Expert Review of Respiratory Medicine·Woo-Jung Song, Kian Fan Chung
May 20, 2020·The Korean Journal of Internal Medicine·Woo-Jung SongLorcan McGarvey
Jun 30, 2019·The European Respiratory Journal·Ayaka AndoMichael J Farrell
Mar 9, 2021·Chest·Peter S P Cho, Richard D Turner
Oct 31, 2020·The European Respiratory Journal·Johnmary T ArinzeGuy G Brusselle
Dec 12, 2020·The European Respiratory Journal·Peter S P ChoSurinder S Birring
May 25, 2021·Frontiers in Physiology·Haodong BaiLi Yu
May 20, 2021·Asia Pacific Allergy·Ha-Kyeong Won, Woo-Jung Song
Jul 16, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Elena KumImran Satia
Jul 1, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Imran SatiaGail M Gauvreau

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