Impaired CXCL4 expression in tumor-associated macrophages (TAMs) of ovarian cancers arising in endometriosis.

Cancer Biology & Therapy
Mitsuko FuruyaIchiro Aoki

Abstract

Inflammatory cells play important roles in progression of solid neoplasms including ovarian cancers. Tumor-associated macrophages (TAMs) contribute to angiogenesis and immune suppression by modulating microenvironment. Ovarian cancer develops occasionally on the bases of endometriosis, a chronic inflammatory disease. We have recently demonstrated differential expressions of CXCR3 variants in endometriosis and ovarian cancers. In this study, we showed impaired CXCL4 expression in TAMs of ovarian cancers arising in endometriosis. The expressions of CXCL4 and its variant CXCL4L1 were investigated among normal ovaries (n = 26), endometriosis (n = 18) and endometriosis-associated ovarian cancers (EAOCs) composed of clear cell (n = 13) and endometrioid (n = 11) types. In addition, four cases of EAOCs that contained both benign and cancer lesions contiguously in single cysts were investigated in the study. Western blot and quantitative RT-PCR analyses revealed significant downregulation of CXCL4 and CXCL4L1 in EAOCs compared with those in endometriosis. In all EAOCs coexisting with endometriosis in the single cyst, the expression levels of CXCL4 and CXCL4L1 were significantly lower in cancer lesions than in corresponding endometriosis...Continue Reading

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Citations

Nov 14, 2014·Journal of Thrombosis and Haemostasis : JTH·F PertuyC Léon
Aug 30, 2013·Journal of Clinical Pathology·Feng-Qin WangYi-Fang Zhao
Sep 25, 2018·Reproductive Sciences·Ding DingSun-Wei Guo
Oct 9, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Beth T Harrison, Khush Mittal
Aug 9, 2018·Cancers·Jillian R Hufgard WendelShannon M Hawkins

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Methods Mentioned

BETA
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