PMID: 2494956Feb 1, 1989Paper

Impaired delayed type cutaneous hypersensitivity in rheumatoid arthritis reversed by chrysotherapy

Annals of the Rheumatic Diseases
M D SmithP J Roberts-Thomson

Abstract

A prospective 24 week study of 31 patients with active rheumatoid arthritis (18 women, 13 men) was undertaken to determine whether weekly intramuscular sodium aurothiomalate (gold) would influence delayed type cutaneous hypersensitivity (DTH) and other indices of cell mediated immunity. DTH to seven recall antigens was measured by Multitest on three occasions during the study. Twenty five patients completed the study. At entry 13 patients (12 female) were anergic, and no significant correlations were found between DTH and other clinical and immunological indices. Women showed a significantly greater depression of DTH than men. At week 24 only three of the patients were anergic with significant increase in mean DTH score being noted particularly to tuberculin, candida, and streptococcus. Improvement in DTH was observed in both gold responders and non-responders. In conclusion, patients with active rheumatoid arthritis show impairment of DTH, which is reversed by chrysotherapy. This effect is most apparent in women and appears to be relatively independent of the clinical response.

References

Jul 1, 1977·Arthritis and Rheumatism·M W DuncanJ T Sharp
Feb 1, 1977·Annals of the Rheumatic Diseases·A A AndrianakosJ Duffy
Jul 1, 1973·Arthritis and Rheumatism·J WaxmanI N Doneson
Dec 1, 1984·Annals of Internal Medicine·J L DeckerR L Wilder
Jan 1, 1984·European Journal of Clinical Pharmacology·Z TrnavskáD Zlnay

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Citations

Mar 30, 2010·Rheumatology International·Tulin CagatayAhmet Gul
Sep 6, 2000·International Journal of Dermatology·S C Behrens-WilliamsK U Schallreuter
Apr 14, 2006·Annals of the Rheumatic Diseases·B E JovenJ L Pablos
Dec 1, 1990·Baillière's Clinical Rheumatology·G D ChampionJ B Ziegler
May 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·I HickieD Wakefield
Feb 28, 2002·BMC Dermatology·Ake SvenssonCarina Linder

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