Impaired dimensional selection but intact use of reward feedback during visual discrimination learning in Parkinson's disease

Neuropsychologia
R SwainsonT W Robbins

Abstract

It has been suggested that Parkinson's disease (PD) impairs the ability to learn on the basis of reward or reinforcing feedback i.e., by trial-and-error. In many learning tasks, particular 'dimensions' of stimulus information are relevant whilst others are irrelevant; therefore, efficient performance depends on identifying the dimensions of these 'compound' stimuli and selecting the relevant dimension for further processing. We investigated the ability of patients with PD, as well as patients with Huntington's disease and patients with frontal or temporal lobe lesions, to learn visual discriminations which required either a number of associations to be learned concurrently (the 'eight-pair' task) or the selection of information from compound stimuli (the 'five-dimension' task), both tasks being learned by trial-and-error. None of the basal ganglia disorder patient groups was impaired on the eight-pair task, militating against a crucial role for these brain structures in trial-and-error learning per se. Patients with mild, medicated PD, but not unmedicated PD patients, were impaired at identifying all five feature dimensions in the five-dimension task, implying dopaminergic 'overdosing' of the ability to analyse compound stimuli...Continue Reading

Citations

Oct 20, 2009·Journal of the International Neuropsychological Society : JINS·Amanda L Price
Oct 1, 2008·Journal of Cognitive Neuroscience·Daphna ShohamyMark A Gluck
Mar 27, 2009·Journal of Cognitive Neuroscience·Roshan CoolsTrevor W Robbins
May 1, 2010·Journal of Cognitive Neuroscience·Sanne de WitRoshan Cools
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth B TorresHoward Poizner
Sep 26, 2008·Cognitive, Affective & Behavioral Neuroscience·Karin M CoxJulie A Fiez
Jan 10, 2012·Neurobiology of Aging·Dario ArnaldiFlavio Nobili
May 3, 2011·Current Opinion in Neurobiology·Roshan Cools
May 12, 2009·Neuropsychologia·Amanda PriceW Todd Maddox
Jul 1, 2008·Neuropsychologia·Leonora WilkinsonMarjan Jahanshahi
Dec 7, 2007·Neuroscience and Biobehavioral Reviews·D ShohamyM A Gluck
Apr 24, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Trevor W Robbins, Roshan Cools
Feb 5, 2008·Neuropsychologia·Henry W ChaseTrevor W Robbins
Dec 17, 2009·Neuropsychologia·Marjan JahanshahiDavid A Lagnado
Aug 9, 2016·Neuroscience and Biobehavioral Reviews·Caroline SeerBruno Kopp
Sep 17, 2020·Learning & Memory·Yi-Wen Wang, F Gregory Ashby

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