PMID: 32521Nov 30, 1978Paper

Impaired distal nephron acidification in chronically phosphate depleted rats

Pflügers Archiv : European journal of physiology
T W Kurtz, C H Hsu

Abstract

Renal tubular bicarbonate reabsorption and acidification were evaluated in phosphate depleted rats (PD) and controls. After 33 days of phosphate depletion, urine pH of PD rats (N = 5, 5.36 +/- 0.15) was significantly higher than control (N = 5, 5.64 +/- 0.09, P less than 0.005) following an NH4Cl load. Urinary titratable acid of PD rats (9.6 +/- 1.8) was significantly reduced compared to control (117.2 +/- 19.7 muEq/3 h, P less than 0.001), whereas NH+4 excretion was not different. The plasma HCO-3 thresholds at which bicarbonaturia occurred (approximately 25 mEq/l) were identical in controls and phosphate depleted rats during isotonic bicarbonate infusion. The higher urine pH of phosphate depleted rats following NH4Cl administration was not due to low urinary phosphate as 3-day phosphate depleted rats could normally acidify urine after NH4Cl (pH = 5.86 +/- 0.09, N = 6 vs. control 5.87 +/- 0.08, N = 6, P = N.S.) despite urinary phosphate excretion as low as in 33-day PD rats. These data indicate the presence of impaired distal tubular acidification in chronically phosphate depleted rats.

References

May 1, 1977·The Journal of Clinical Investigation·S GoldfarbZ S Agus
Oct 1, 1977·The Journal of Clinical Investigation·J A ArrudaN A Kurtzman
Dec 1, 1974·The American Journal of Physiology·H R HarterS Klahr
Dec 18, 1969·The New England Journal of Medicine·R C Morris
Jun 1, 1970·The Journal of Clinical Investigation·J W Coburn, S G Massry
Feb 22, 1968·The New England Journal of Medicine·M LotzF C Bartter
Sep 1, 1969·The Journal of Clinical Investigation·M L PurkersonN S Bricker
Jul 1, 1955·The American Journal of Physiology·E LEONARD, J ORLOFF
Nov 1, 1947·The American Journal of Physiology·R W LIPPMAN

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Citations

Sep 1, 1980·Metabolism: Clinical and Experimental·J A ArrudaN A Kurtzman

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