PMID: 3770043Jul 1, 1986Paper

Impaired DNA-repair synthesis in lymphocytes of breast cancer patients

European Journal of Cancer & Clinical Oncology
E KovacsH Müller

Abstract

UV-C light induced DNA-repair synthesis was studied in unstimulated lymphocytes of 41 female patients (aged 33-83 years) with invasive breast cancer and of 27 healthy women (aged 37-68 years). As a parameter for the determination of the DNA-repair synthesis the incorporation of [3H] thymidine was taken in the presence of 2 mM hydroxyurea (HU). The [3H] thymidine incorporation levels were reduced in 20 of the 41 patients and in only 3 of the 27 controls. This difference between the two groups was significant. An impaired DNA-repair synthesis might be involved in the etiology of breast cancer in some patients.

References

Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·A R Lehmann
Jan 1, 1980·Environmental Mutagenesis·J Irwin, B Strauss

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Citations

Jan 1, 1992·Archives of Gynecology and Obstetrics·E KovacsH Ludwig
Dec 26, 2007·Pathology Oncology Research : POR·Stephen G GrantJean J Latimer
Jun 14, 2008·Breast Cancer Research and Treatment·Jiali HanDavid J Hunter
Dec 1, 1993·Mutation Research·Z Djuric, D Kritschevsky
Jul 1, 1997·The Journal of Laboratory and Clinical Medicine·U GafterH Breitbart
Dec 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jean J LatimerStephen G Grant
Aug 12, 2010·The Journal of Biological Chemistry·Tadi Satish KumarSathees C Raghavan
Aug 1, 1993·Kidney International·T MalachiJ Levi
Mar 1, 1988·Cancer Treatment Reviews·R J Epstein
Jul 1, 1987·European Journal of Cancer & Clinical Oncology·E Kovacs, A Almendral
Oct 31, 2001·Public Health Nutrition·P Vineis
Jan 1, 1990·Pediatric Hematology and Oncology·V A Bohr, M K Evans
Jun 17, 2000·American Journal of Clinical Oncology·M S SimonZ Djuric
Jan 1, 2000·Psychology & Health·Michael J ForlenzaAndrew Baum
Feb 6, 2020·International Journal of Molecular Sciences·Sylwia PietrasikJanusz Blasiak
May 19, 2010·Mutation Research·Ilse DecordierMicheline Kirsch-Volders

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