PMID: 152412Oct 16, 1978

Impaired dopamine function and muscular rigidity induced by 6-aminonicotinamide in rats

Naunyn-Schmiedeberg's Archives of Pharmacology
W KehrH Herken

Abstract

In corpus striatum, 6-aminonicotinamide (6-AN), 10 mg/kg i.p. lowered the concentration of dopamine and markedly reduced the disappearance of dopamine after synthesis inhibition with alpha-methyl-p-tyrosine. In the dopamine-rich part of the limbic system, the formation of DOPA after decarboxylase inhibition with 3-hydroxybenzylhydrazine was decreased. In diencephalon, 6-AN altered neither the steady-state level nor the utilization of noradrenaline. The data suggest that the muscular rigidity induced by 6-AN may be associated with disruption of dopaminergic transmission.

References

Jan 1, 1976·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·I Jurna
Mar 31, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·R Bock
Nov 10, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·D LoosH Herken
Jan 1, 1976·Journal of Neural Transmission·W KehrA CARLSSON
Jun 1, 1973·The Journal of Pharmacy and Pharmacology·A CARLSSON, M Lindqvist
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·W KehrM Lindqvist
Dec 15, 1958·Acta Physiologica Scandinavica·A BERTLERE ROSENGREN

Related Concepts

Brain Chemistry
Catecholamines
Intropin
Hydrazines
Methyltyrosines
Nuchal Rigidity
Enduramide
6-Aminonicotinamide

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