Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas

Pancreas
Virginie AudardJean-François Flejou

Abstract

To analyze in solid pseudopapillary neoplasm of the pancreas (SPNP) the consequences of the deregulated Wnt pathway by studying the expression of Wnt target glutamine synthetase (GLUL), cyclin D1, and E-cadherin, which is one of the beta-catenin binding partner in cell adhesion. The expression of cyclin D1 and GLUL was studied at the protein and/or messenger RNA levels, and the immunolocalization for E-cadherin was analyzed in 28 SPNPs screened for beta-catenin mutations. Expression of cyclin D1, GLUL, and beta-catenin was also assessed in pancreatic endocrine tumors as controls. Cytosolic and/or nuclear accumulation of beta-catenin was observed in all tumors; an activating beta-catenin mutation was identified in 21 (91%) of 23 tumors analyzed. E-cadherin expression is lost from the membrane and is observed in intracytosolic "dotlike" structures. Whereas cyclin D1 expression is observed widely in SPNP and endocrine tumors, GLUL expression is restricted to SPNP (100%) and rare endocrine tumors (10%) displaying Wnt activation. The activation of the Wnt/beta-catenin pathway in SPNP has 2 main consequences. First, E-cadherin expression moved from membranous to intracytoplasmic localization. Second, GLUL expression is highly correla...Continue Reading

References

Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·A de La CosteC Perret
Aug 26, 1998·The American Journal of Pathology·S Hirohashi
Nov 5, 1999·Digestion·B GerdesD Bartsch
Jul 6, 2000·Virchows Archiv : an International Journal of Pathology·M KosmahlG Klöppel
Feb 9, 2002·Annals of Surgical Oncology·Robert C G MartinKevin C Conlon
Mar 6, 2004·Science·W James Nelson, Roel Nusse
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christine OvejeroChristine Perret
Jul 21, 2004·The Journal of Cell Biology·Genkichi IzumiYoshimi Takai
Aug 17, 2004·Trends in Cell Biology·David M Bryant, Jennifer L Stow
May 30, 2006·Journal of Clinical Pathology·V HervieuJ-Y Scoazec

❮ Previous
Next ❯

Citations

Jun 25, 2013·Neurochemistry International·Tore EidJames C K Lai
Nov 29, 2012·The Cancer Journal·Laura D Wood, Ralph H Hruban
Jun 27, 2008·Advances in Anatomic Pathology·Chanjuan ShiRalph H Hruban
Jun 27, 2008·Advances in Anatomic Pathology·Runjan Chetty, Stefano Serra
Mar 26, 2011·Medical Hypotheses·Hans O Kalkman
Mar 15, 2011·Annals of Diagnostic Pathology·Mishie TaninoShinya Tanaka
Feb 25, 2011·Clinics and Research in Hepatology and Gastroenterology·Thomas WalterJean-Yves Scoazec
Apr 14, 2009·Human Pathology·Ralph H Hruban, N Volkan Adsay
Dec 17, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·D AntonelloA Scarpa
Aug 30, 2012·Journal of Cellular Biochemistry·Jong-Ho ChoiKwang-Hyun Baek
Sep 15, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Irene EspositoGünter Klöppel
Jan 4, 2015·Carcinogenesis·Anita BoppGerhard Fritz
Dec 3, 2014·Journal of Affective Disorders·V A L MináM L N Rolim
Mar 3, 2015·Seminars in Oncology·Arvind RishiRalph H Hruban
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Fan LinHanlin L Wang
Dec 20, 2014·Seminars in Diagnostic Pathology·Benoît Terris, Catherine Cavard
Sep 11, 2016·Journal of Neuroinflammation·Victoria LutgenLena Al-Harthi
Jul 1, 2017·Archives of Pathology & Laboratory Medicine·Peyman Dinarvand, Jinping Lai
Jan 21, 2020·Archives of Pathology & Laboratory Medicine·Stefano La Rosa, Massimo Bongiovanni
Jul 15, 2020·Current Hypertension Reports·Yves LecarpentierAlexandre Vallée
Aug 24, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Stephen M LaganaFei Bao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.