PMID: 12464084Dec 5, 2002Paper

Impaired egress rather than increased access: an important independent predictor of erosive oesophagitis

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
M P JonesP J Kahrilas

Abstract

Oesophagitis severity is related to total oesophageal acid exposure, which is in turn dependent upon both the number reflux events and the rate of refluxate clearance. This study examined differences in the frequency of reflux events and the characteristics of oesophageal acid exposure in asymptomatic controls and gastro-oesophageal reflux disease (GORD) patients both with and without oesophagitis. Nine controls and 38 patients with GORD were studied. All patients underwent upper endoscopy, videofluoroscopy, determination of resting lower oesophageal sphincter pressure (LOSP) and 24 h pH monitoring. Analysis was performed with subjects grouped as controls, non-erosive GORD and oesophagitis. A second analysis was performed with subjects grouped by hiatal hernia size. Statistical comparisons were made using anovaand unpairedt-tests. Patients with oesophagitis had significantly larger hiatal hernias, greater oesophageal acid exposure, more prolonged episodes of reflux and longer acid clearance times than did controls and patients with non-erosive GORD. No significant difference was seen in the number of reflux events. Increasing hiatal hernia size was significantly associated with increasing oesophageal acid exposure, number of pr...Continue Reading

References

Mar 1, 1991·Gastroenterology·S Sloan, P J Kahrilas
Jun 1, 1991·The American Journal of Medicine·M A KorstenA Biener
Oct 1, 1986·Gastroenterology·P J KahrilasA Reece
May 1, 1985·The British Journal of Surgery·G J MaddernG G Jamieson
Feb 1, 1980·The Journal of Clinical Investigation·J DentD J Petrie
Aug 1, 1995·Gastroenterology·R K MittalJ Dent

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Citations

Sep 20, 2011·Gut and Liver·Jong Jin Hyun, Young-Tae Bak
Mar 13, 2014·Gut·Guy BoeckxstaensPeter J Kahrilas
Dec 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Benson T Massey
Feb 8, 2014·Gastroenterology Clinics of North America·Guy E Boeckxstaens, Wout O Rohof
Oct 16, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jacqueline LeeMark Fox
Sep 24, 2004·Alimentary Pharmacology & Therapeutics·C GordonJ D Maxwell
Sep 2, 2004·Alimentary Pharmacology & Therapeutics·S NandurkarN J Talley
Mar 25, 2006·Alimentary Pharmacology & Therapeutics·S EmerenzianiM Cicala
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F CremoniniN J Talley
Jan 29, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C DaumM Fox
Jan 27, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P W WeijenborgA J Bredenoord
Aug 25, 2004·Best Practice & Research. Clinical Gastroenterology·Eamonn M M Quigley
Apr 25, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·D M GrayC P Gyawali
Jun 9, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T V K HerregodsA J P M Smout
Aug 21, 2014·Journal of Pediatric Gastroenterology and Nutrition·Elena ScarpatoErasmo Miele
Feb 17, 2018·Expert Review of Gastroenterology & Hepatology·Hai-Xiang YuHua Xin
Jun 12, 2018·Annals of the New York Academy of Sciences·Jingbo ZhaoHans Gregersen
Nov 24, 2004·The American Journal of Gastroenterology·Daniel Sifrim, Xin Zhang
Apr 28, 2007·Journal of Gastroenterology·Sumio WatanabeAkihito Nagahara
Aug 19, 2007·European Journal of Gastroenterology & Hepatology·Fernando FornariSérgio G S Barros
Sep 21, 2007·Journal of Clinical Gastroenterology·Spiros N SgourosApostolos Mantides
Jan 15, 2015·Postgraduate Medical Journal·Guy BoeckxstaensPeter J Kahrilas
May 16, 2006·Arquivos De Gastroenterologia·Luiz João AbrahãoRosana Bihari Schechter
May 24, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Tomohide TanabeKatsuhiko Iwakiri
Oct 29, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Paola IovinoNigel Trudgill

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