Impaired expansion of regulatory T cells in a neonatal thymectomy-induced autoimmune mouse model

The American Journal of Pathology
Akiko YamadaNaozumi Ishimaru

Abstract

Neonatal thymectomy in certain mouse strains is known to induce organ-specific autoimmunity due to impaired functions of T cells, including Foxp3(+) regulatory T (Treg) cells in the thymus. The precise mechanism underlying the induction of autoimmunity by neonatal thymectomy remains unclear. One possibility is that depletion of Treg cells breaks down peripheral tolerance. We examined the functions of Treg cells by using a murine Sjögren syndrome model of NFS/sld mice that underwent neonatal thymectomy. The ratio of Treg cells to effector memory phenotype T cells in thymectomy mice was significantly lower than that of nonthymectomy mice. In addition, in vitro induction of peripherally induced Treg cells by transforming growth factor-β (TGF-β) using naive T cells from Sjögren syndrome model mice was severely impaired. The mRNA expression of TGF-β receptor I and II and Smad3 and -4 in the TGF-β-induced signal transduction pathway of Treg cells in this Sjögren syndrome model were lower than those of control mice. In addition, Treg cells in this Sjögren syndrome model exhibited an interferon-γ-producing Th1-like phenotype that resembled effector T cells. In conclusion, these results suggest that abnormal expansion and differentiatio...Continue Reading

References

Jan 1, 1981·Immunogenetics·A Kojima, R T Prehn
Feb 1, 1995·Immunology Today·A BonomoE M Shevach
Aug 1, 1996·The Journal of Experimental Medicine·M AsanoS Sakaguchi
Aug 7, 2002·The Journal of Clinical Investigation·Kaoru SaegusaYoshio Hayashi
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Sep 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Helene C DujardinAntonio Bandeira
Mar 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kui Shin VooYong-Jun Liu
Oct 12, 2010·Science·Yuri P RubtsovAlexander Y Rudensky
May 5, 2011·Nature Medicine·Margarita Dominguez-VillarDavid A Hafler
Sep 12, 2012·The Journal of Experimental Medicine·Mahesh YadavJeffrey A Bluestone

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Citations

Mar 22, 2016·The Journal of Clinical Investigation·Nadine DraginSonia Berrih-Aknin
Jan 11, 2020·Frontiers in Immunology·Hao Shi, Hongbo Chi
Apr 10, 2020·Nature Reviews. Immunology·Liliana E Lucca, Margarita Dominguez-Villar
Jun 22, 2018·Nature Immunology·Margarita Dominguez-Villar, David A Hafler
Nov 19, 2018·Clinical Reviews in Allergy & Immunology·Runze QiuDongping Yuan
Jul 23, 2020·Frontiers in Immunology·Yunzhen GaoJunfeng Zheng
Nov 15, 2020·Biomolecules·William de Jesús Ríos-RíosHonorio Torres-Aguilar
Jul 22, 2021·The Journal of Investigative Dermatology·Victoire GouirandMichael D Rosenblum

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