Impaired fatty acid oxidation in muscle of aging rats perfused under basal conditions

American Journal of Physiology. Endocrinology and Metabolism
M Z Tucker, L P Turcotte

Abstract

The purpose of the present study was to examine the utilization of fatty acids (FA) and muscle substrates by skeletal muscle in young, middle-aged, and old adult rats under conditions of euglycemia with low insulin levels. Male Fischer 344 x Brown Norway rats aged 5, 15, or 24 mo underwent hindlimb perfusion with a medium of 8 mM glucose, 1 mM palmitate, 25 microU/ml insulin, [1-(14)C]palmitate, and [3-(3)H]glucose. Glucose and palmitate uptake were similar among age groups. The percent and total palmitate oxidized (nmol.min(-1).g(-1)) were 30-36 and 41-49% lower (P < 0.05) in 15-mo- and 24-mo-old than in 5-mo-old animals. Compared with 5-mo- and 15-mo-old animals, pre- and postperfusion muscle triglyceride (TG) levels were significantly (P < 0.05) elevated 91-305% in red and 118-219% in white muscles of 24-mo-old animals. Fatty acid-binding protein content was 40-64% higher (P < 0.05) in 24-mo- than in 5-mo- or 15-mo-old animals. In red muscle, hormone-sensitive lipase (HSL) content was 28% lower (P < 0.05) in 24-mo- than in 5-mo-old animals. These results indicate that, under euglycemic conditions in the presence of low insulin levels, the reduction in FA disposal to oxidation and the decrease in HSL content may contribute to...Continue Reading

References

Oct 1, 1992·Metabolism: Clinical and Experimental·B GumbinerR R Henry
Oct 1, 1991·Mechanisms of Ageing and Development·J O HolloszyJ C Young
Aug 1, 1990·The American Journal of Physiology·W W WinderD Cartmill
Jun 1, 1989·Journal of Applied Physiology·J L IvyG M Kastello
Mar 1, 1987·Journal of Gerontology·E Dall'AglioS Azhar
Feb 1, 1986·Journal of Applied Physiology·L L SprietN L Jones
Jun 1, 1983·The Journal of Clinical Investigation·R I FinkJ M Olefsky
Jun 1, 1983·The Journal of Clinical Investigation·J W RoweJ S Flier
Nov 1, 1984·The American Journal of Anatomy·R B Armstrong, R O Phelps
Aug 1, 1983·The American Journal of Physiology·B G Mackie, R L Terjung
Oct 1, 1995·The American Journal of Physiology·L S SidossisR R Wolfe
Jan 1, 1995·Journal of Applied Physiology·J Calles-EscandónE T Poehlman
Mar 1, 1994·The American Journal of Physiology·R C BonadonnaR A DeFronzo
Mar 1, 1996·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M Brown, E M Hasser
Sep 1, 1996·The American Journal of Physiology·L BudohoskiR L Terjung
Jun 1, 1997·The American Journal of Physiology·L S SidossisR R Wolfe
Nov 15, 1997·Metabolism: Clinical and Experimental·J Calles-EscandónE García-Rubí
Apr 8, 1998·The American Journal of Physiology·L S SidossisA R Coggan
Jun 6, 1998·Journal of Applied Physiology·Z Guo, M D Jensen
Aug 4, 1998·The American Journal of Physiology·S J PetersL L Spriet
Apr 13, 1999·The American Journal of Physiology·A BonenN A Abumrad
Feb 15, 2000·The Journal of Biological Chemistry·G M CliffordS J Yeaman
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·E C StarrittL L Spriet
Sep 8, 2000·Molecular and Cellular Biochemistry·L P TurcotteA Bonen

❮ Previous
Next ❯

Citations

Jul 26, 2007·Lipids in Health and Disease·ZengKui Guo
Oct 5, 2013·Disease Models & Mechanisms·Fabio DemontisNorbert Perrimon
Apr 9, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle Z Tucker, Lorraine P Turcotte
May 24, 2006·Molecular and Cellular Biochemistry·Arend BonenJoost J F P Luiken
Jun 6, 2009·Ageing Research Reviews·Lydia W S Finley, Marcia C Haigis
Mar 10, 2015·Computational and Structural Biotechnology Journal·Mark T Mc Auley, Kathleen M Mooney
Sep 20, 2011·Journal of Cellular Physiology·Sébastien MichelPatricia Renard
Oct 15, 2013·FEMS Yeast Research·Tobias Eisenberg, Sabrina Büttner
Jul 20, 2016·Annual Review of Nutrition·Brandon J F GhellerAnna E Thalacker-Mercer
Feb 23, 2012·Scientific Reports·Riekelt H HoutkooperJohan Auwerx
Oct 5, 2002·Journal of Lipid Research·Fredric B Kraemer, Wen-Jun Shen
Oct 16, 2015·Medicine and Science in Sports and Exercise·John J DubéFrancesca Amati
Jul 27, 2017·Frontiers in Endocrinology·Cyrielle BillonThomas P Burris
May 4, 2018·Archives of Insect Biochemistry and Physiology·Cheng-Yen LuChin-Yuan Hsu
Jun 5, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michelle Z Tucker, Lorraine P Turcotte
Jan 10, 2021·Biology·Francesco BellantiGianluigi Vendemiale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.