Impaired fatty acid uptake in ischemic but viable myocardium identified by thallium-201 reinjection

American Heart Journal
I MatsunariK Hisada

Abstract

Iodine 123-labeled 15-iodophenyl-3-methyl-pentadecanoic acid (BMIPP) has been proposed as a potential myocardial fatty acid probe. We studied BMIPP uptake in ischemic myocardium identified by thallium reinjection. Fifty-five patients with coronary artery disease who had persistent defects on standard exercise-redistribution thallium imaging were investigated. Patients underwent exercise-redistribution-reinjection thallium and resting BMIPP imaging. BMIPP uptake less than that seen with thallium on reinjection imaging was observed in 105 (82%) of 128 myocardial segments with new fill-in after thallium reinjection and 87 (37%) of 238 segments with reversible thallium defects. In contrast, only 32 (19%) of 166 segments with no fill-in showed discordantly decreased BMIPP uptake. Quantitative analysis showed reduction in BMIPP activity compared with differential uptake of thallium, an index of resting myocardial perfusion, especially in the area of fill-in (53.5% +/- 15.0% vs 76% +/- 12.1% of peak; p<0.01). These observations are consistent with impaired fatty acid uptake in ischemic myocardium, particularly in the area of fill-in after thallium reinjection.

References

Jan 1, 1986·European Journal of Nuclear Medicine·F F KnappM M Goodman
Jan 1, 1986·European Journal of Nuclear Medicine·R DudczakM M Goodman
Nov 1, 1968·American Heart Journal·L H Opie

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Citations

May 5, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Junichi Taki, Ichiro Matsunari
Jul 9, 2003·Annals of Nuclear Medicine·Ichiro MatsunariKinichi Hisada
Mar 18, 1999·The American Journal of Cardiology·S Iskander, A E Iskandrian
Dec 17, 2010·World Journal of Cardiology·Shinro MatsuoSeigo Kinuya
Aug 29, 2006·Heart Failure Reviews·Roxy Senior

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