Impaired Fertility Associated with Subclinical Hypothyroidism and Thyroid Autoimmunity: The Danish General Suburban Population Study

Journal of Pregnancy
Anne-Dorthe FeldthusenJan Kvetny

Abstract

The aim of this study was to estimate the significance of TSH, thyroid peroxidase antibody (TPOAb), and mild (subclinical) hypothyroidism in women from The Danish General Suburban Population Study (GESUS) on the number of children born, the number of pregnancies, and the number of spontaneous abortions. Retrospective cross sectional study of 11254 women participating in GESUS. Data included biochemical measurements and a self-administrated questionnaire. 6.7% had mild (subclinical) hypothyroidism and 9.4% prevalent hypothyroidism. In women with mild hypothyroidism TPOAb was significantly elevated and age at first child was older compared to controls. TSH and TPOAb were negatively linearly associated with the number of children born and the number of pregnancies in the full cohort in age-adjusted and multiadjusted models. TSH or TPOAb was not associated with spontaneous abortions. Mild (subclinical) hypothyroidism was associated with a risk of not having children and a risk of not getting pregnant in age-adjusted and multiadjusted models. Prevalent hypothyroidism was not associated with the number of children born, the number of pregnancies, or spontaneous abortions. Impaired fertility is associated with TSH, TPOAb, and mild (su...Continue Reading

References

Mar 1, 2000·Archives of Internal Medicine·G J CanarisE C Ridgway
Feb 13, 2002·Thyroid : Official Journal of the American Thyroid Association·M AbalovichO Levalle
Feb 3, 2005·Obstetrics and Gynecology·Brian M CaseyF Gary Cunningham
Nov 2, 2006·Obstetrics and Gynecology·Brian M Casey, Kenneth J Leveno
Jul 2, 2008·Obstetrics and Gynecology·Jane Cleary-GoldmanMary E D'Alton
Jan 19, 2010·The Journal of Clinical Endocrinology and Metabolism·Tuija MännistöEila Suvanto
Jun 7, 2011·Journal of Endocrinological Investigation·S WangZ Y Shan
Aug 23, 2011·Clinical Obstetrics and Gynecology·Alex Stagnaro-Green
Jan 25, 2012·Obstetrics and Gynecology·Karen L WilsonF Gary Cunningham
Jan 26, 2012·Lancet·David S Cooper, Bernadette Biondi
Mar 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Lily L SomwaruAnne R Cappola
Jan 1, 2012·International Journal of Applied & Basic Medical Research·Indu VermaSatinder Kaur
Aug 5, 2014·Thyroid : Official Journal of the American Thyroid Association·Haixia LiuWeiping Teng

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Citations

Dec 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Tahereh Orouji JokarPouneh K Fazeli
Apr 17, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Bingjie ZhangYan Bi
Sep 15, 2018·Experimental and Therapeutic Medicine·Xianping WangRui Fang
Jun 1, 2018·Journal of the Endocrine Society·Spyridoula MarakaDerek T O'Keeffe
Jun 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Rima K Dhillon-SmithArri Coomarasamy
Mar 10, 2016·Journal of Endocrinological Investigation·G MintzioriD G Goulis

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