PMID: 16522281Mar 9, 2006Paper

Impaired fibrinolysis and risk for cardiovascular disease in the metabolic syndrome and type 2 diabetes

Current Diabetes Reports
Susanne TrostBurton E Sobel

Abstract

Patients with the metabolic syndrome are insulin resistant and manifest a cluster of risk factors for cardiovascular disease. Impaired fibrinolysis and increased concentrations in blood of plasminogen activator inhibitor-1 (PAI-1) are related to insulin resistance and abdominal obesity and may contribute to the increased risk for cardiovascular disease in this group. Weight loss, metformin, and thiazolidinediones ameliorate insulin resistance and decrease concentrations of PAI-1. Thus, they may lower risk in patients with the metabolic syndrome.

References

Jan 1, 1979·Circulation·W B Kannel, D L McGee
Nov 16, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·G UrdénB Wiman
Apr 11, 1996·The New England Journal of Medicine·J P DesprésP J Lupien
Jul 1, 1996·The American Journal of Clinical Nutrition·J Calles-EscandonB Sobel
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·D A EhrmannK S Polonsky
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·D J SchneiderB E Sobel
May 13, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B Janand-DelenneP Vague
Apr 20, 1999·JAMA : the Journal of the American Medical Association·K GuM I Harris
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·F SamadD J Loskutoff
Jun 11, 1999·Journal of Internal Medicine·S SöderbergB Ahrén
Jun 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·A MavriB R Binder
Oct 16, 1999·Journal of the American College of Cardiology·P R MorenoI F Palacios
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Jun 15, 2000·The New England Journal of Medicine·H P Kohler, P J Grant

❮ Previous
Next ❯

Citations

Aug 11, 2012·Stroke; a Journal of Cerebral Circulation·Anna Tjärnlund-WolfXiaoying Wang
Apr 24, 2009·Clinical and Experimental Hypertension : CHE·Katsutaka Oishi
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Sep 29, 2011·Metabolism: Clinical and Experimental·Elizabeth FragopoulouSmaragdi Antonopoulou
Oct 31, 2009·Advances in Medical Sciences·M GnacińskaK Sworczak
Nov 13, 2007·Thrombosis Research·Massimo FranchiniGiuseppe Lippi
Jun 5, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Emily CozziRuth Ann Henriksen
Nov 28, 2008·Journal of Thrombosis and Haemostasis : JTH·K H BorchJ-B Hansen
Nov 29, 2011·Journal of Vascular Surgery·Jose A DiazThomas W Wakefield
Mar 14, 2017·Archives of Physical Medicine and Rehabilitation·Masahiro Horiuchi, Koichi Okita
Nov 26, 2009·The Journal of International Medical Research·M Marinsek, Andreja Sinkovic
Mar 17, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Baris AkinciSena Yesil
Jun 3, 2017·Journal of the American Heart Association·Poornima VenkatJieli Chen
Aug 26, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Marie-Christine Alessi, Irène Juhan-Vague
Oct 31, 2009·Stroke; a Journal of Cerebral Circulation·Ayoze N Gonzalez-HernandezSantiago Diaz-Nicolas
Mar 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dan AtarVictor L Serebruany
May 15, 2007·Current Opinion in Lipidology·Marie-Christine AlessiIrène Juhan-Vague
Jul 14, 2007·Coronary Artery Disease·Michaelanne RowenBurton E Sobel
Apr 18, 2007·Clinical Pharmacology and Therapeutics·W T CefaluS Ryder
Apr 25, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Anirudh KumarVenu Menon
Oct 26, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gary P Van GuilderChristopher A DeSouza
Sep 5, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mikael EkholmN Håkan Wallén
Apr 24, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Paul S JellingerUNKNOWN AACE Task Force for Management of Dyslipidemia and Prevention of Atherosclerosis
Sep 15, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mustafa ÇetinerYaşar Zorlu
Apr 25, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Paul S JellingerMichael Davidson
Apr 4, 2021·International Journal of Molecular Sciences·Rawan AltalhiRamzi A Ajjan
Mar 2, 2018·Thrombosis Research·Richard G JungBenjamin Hibbert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.