Impaired fibrinolysis in premenopausal women and age-matched men with Type 2 diabetes mellitus: a pilot study

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
S L BrandenburgJ G Regensteiner

Abstract

The presence of Type 2 diabetes mellitus (DM) is one of the strongest predictors of cardiovascular disease (CVD) in women. Although the specific mechanisms underlying this increased risk are unknown, one factor that may contribute to CVD in women with Type 2 DM is impaired fibrinolysis. Healthy premenopausal women have a low rate of CVD and excellent fibrinolytic potential. Impairment in fibrinolysis in people with DM has been demonstrated mainly in men, whereas the fibrinolytic potential of women with Type 2 DM has not been characterized well. This pilot study compared fibrinolytic measures in premenopausal women and men with DM with those of healthy age-matched control women and men to help determine whether fibrinolysis is abnormal in women with DM. Fibrinolytic measurements included euglobulin clot lysis time (ELT), fibrinogen, plasminogen activator inhibitor 1, and tissue-type plasminogen activator. Poststasis ELT was significantly impaired in the women with DM as compared with the control women. The men with DM had a tendency toward slower poststasis ELT than did the control men, but the differences between the men's groups were not significant. In the women's groups only, we observed a trend toward increased plasminogen ...Continue Reading

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Citations

Dec 14, 2004·The American Journal of Medicine·Gjin NdrepepaAdnan Kastrati
Sep 17, 2002·The American Journal of Cardiology·Jane E B Reusch
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Aditya GoelRoshanak Rahimian
Jul 16, 2020·Journal of the Endocrine Society·Layla A AbushamatJane E B Reusch

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