Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: the effect of genetic loading.

Schizophrenia Bulletin
Shu-Sen ChangWei J Chen

Abstract

We previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia. This study compared the niacin flush response in subjects from families with only one member affected with schizophrenia (simplex families) with those from families having a sib-pair with schizophrenia (multiplex families). Subjects were patients with schizophrenia and their nonpsychotic first-degree relatives from simplex families (176 probands, 260 parents, and 80 siblings) and multiplex families (311 probands, 180 parents, and 52 siblings) as well as 94 healthy controls. Niacin patches of 3 concentrations (0.001M, 0.01M, and 0.1M) were applied to forearm skin, and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. More attenuated flush response to topical niacin was shown in schizophrenia probands and their relatives from multiplex families than in their counterparts from simplex families, and the differentiation was better revealed using 0.1M concentration of niacin than 0.01M or 0.001M. For the highest concentration of 0....Continue Reading

References

Apr 15, 1991·Biological Psychiatry·J Rybakowski, R Weterle
Jul 1, 1989·Schizophrenia Research·M J LyonsM T Tsuang
Jan 1, 1989·Schizophrenia Bulletin·K S KendlerD Walsh
Sep 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·S W LewisR M Murray
Jun 1, 1994·The American Journal of Psychiatry·M A Roy, R R Crowe
Aug 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A I GlenD F Horrobin
Mar 28, 1998·Schizophrenia Research·P E WardA I Glen
Jun 13, 2002·The Australian and New Zealand Journal of Psychiatry·Gregor E BergerPatrick D McGorry
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Basant K Puri, Iqbal Singh
Mar 22, 2003·Schizophrenia Research·Hildeberto TavaresWagner F Gattaz
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Jul 3, 2003·Schizophrenia Research·Erik MessamoreAaron Janowsky
Sep 18, 2003·Biological Psychiatry·Annamari Tuulio-HenrikssonJouko Lönnqvist
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Roderick MacleanBrian M Ross
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Erik Messamore
Apr 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Brian M RossJerry J Warsh
Apr 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jonathan CovaultHenry R Kranzler
Feb 3, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hai-Gwo HwuMing T Tsuang
Feb 15, 2005·BMC Medical Genetics·Daniel R Hanson, Irving I Gottesman
May 12, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S SmesnyH Sauer
Jul 16, 2005·Journal of Internal Medicine·L A Carlson
Jul 14, 2006·Psychiatry Research·Linda Bosveld-van HaandelRobert J van den Bosch

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Citations

Mar 16, 2011·International Journal of Clinical Practice·A S Wierzbicki
Sep 26, 2008·BMC Research Notes·Brian M Ross, Martin Katzman
May 28, 2010·International Review of Psychiatry·Brendan P Murphy
Dec 12, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sergej NadalinAlena Buretić-Tomljanović
Jun 29, 2010·Psychiatry Research·Raúl MendozaMigdyrai Martín Reyes
Oct 30, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B M NilssonL Ekselius
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Wei J Chen
Apr 27, 2010·Schizophrenia Research·Erik MessamoreJeffrey K Yao
Aug 30, 2014·European Psychiatry : the Journal of the Association of European Psychiatrists·B M NilssonL Ekselius
Oct 2, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Stefan SmesnyBernhard Blanz

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