Impaired gas mixing and low lung volume in preterm infants with mild chronic lung disease

Pediatric Research
H ShaoO Hjalmarson

Abstract

The aim of this study was to assess the possible role of gas mixing inefficiency in spontaneously breathing infants with mild chronic lung disease (CLD) of prematurity in relation to changes in other functional parameters. A simple bedside technique for recording and analysis of multiple breath nitrogen washout curves was applied together with occlusion mechanics. Fifteen preterm infants with mild or moderately severe CLD were studied at a mean postconceptional age of 35 wk, together with 15 healthy preterm infants at the same maturity. All infants breathed spontaneously, and the test was performed by a continuous bypass flow system, connected to a face mask, a pneumotachograph, and a nitrogen meter. The results showed impaired gas mixing with moment ratios above the 95th percentile of the normal group in 11/15 infants with CLD. Functional residual capacity (FRC) was low in 13/15 infants, but specific compliance and resistance of the respiratory system did not differ between the groups. As FRC and moment ratios were not correlated, it is suggested that they may reflect different aspects of the pathophysiology in CLD. It is concluded that low FRC and disturbed gas mixing are characteristic disturbances in CLD at different degree...Continue Reading

References

Jun 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J SaniieE H Chester
Mar 1, 1976·Journal of Applied Physiology·G R Weygandt
Feb 1, 1975·Journal of Applied Physiology·G M SaidelE H Chester
Jul 1, 1987·Physiological Reviews·M Paiva, L A Engel
May 1, 1987·Early Human Development·A A HislopV Aber
Dec 1, 1986·The Journal of Pediatrics·R S TepperL M Taussig
Mar 1, 1987·The Journal of Pediatrics·T GerhardtE Bancalari
Jan 1, 1986·Medical & Biological Engineering & Computing·B A SjöqvistT Olsson
Jan 1, 1985·Journal of Applied Physiology·C L BowesK Horsfield
Oct 1, 1985·Journal of Applied Physiology·R Kraemer, B Meister
Jun 1, 1984·Archives of Disease in Childhood·K SandbergT Olsson
Jan 1, 1980·Respiration; International Review of Thoracic Diseases·E SvenoniusT Lindberg
Apr 1, 1995·The Journal of Pediatrics·M A RojasG Silva-Neto
Apr 1, 1994·Pediatric Clinics of North America·S H Abman, J R Groothius
Feb 1, 1997·Pediatric Pulmonology·A A Hislop
Jan 1, 1956·Journal of Applied Physiology·A B OTISE P RADFORD
May 1, 1959·Journal of Applied Physiology·W A BRISCOE, A COURNAND
Nov 1, 1961·Journal of Applied Physiology·A BOUHUYSG LUNDIN
Jan 1, 1952·The Journal of Clinical Investigation·W S FOWLERS S KETY

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Citations

Jun 7, 2005·European Journal of Pediatrics·Anne GreenoughJaana A Leipälä
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Ola Hjalmarson, Kenneth Sandberg
Apr 24, 2013·Annals of the American Thoracic Society·Margaret RosenfeldUNKNOWN American Thoracic Society Assembly on Pediatrics Working Group on Infant and Preschool Lung Function Testing
Dec 22, 2009·The Journal of Pediatrics·Sven M SchulzkeJ Jane Pillow
Dec 22, 2009·Pediatric Pulmonology·Sanjay SinhalJ Jane Pillow
Jan 13, 2005·The Journal of Pediatrics·Ola Hjalmarson, Kenneth L Sandberg
Jun 19, 2015·Physiological Measurement·Gerd SchmalischHendrik S Fischer

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