Impaired gastric myolectrical activity in patients with cystic fibrosis

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Lea BenturDrora Berkowitz

Abstract

Cystic fibrosis (CF) is frequently associated with gastrointestinal complaints that can be due to gastrointestinal dysmotility. Electrogastrography (EGG) is an attractive, non-invasive procedure to assess gastric electric activity. The aims of our study were to investigate EGG abnormalities in pancreatic sufficient and pancreatic insufficient CF patients, and to examine whether EGG correlates with gastric emptying as assessed by scintigraphy. EGG was performed in 23 CF patients (12 pancreatic sufficient patients, 11 pancreatic insuffficient) by using cutaneous recording pre- and postprandialy. Pre- and postpostprandial EGG indexes were compared to 19 healthy control patients. Gastric emptying was assessed simultaneously by gastric scintigraphy in 11 of the 23 CF patients. Six patients underwent a repeated scintigraphy recording following a month of treatment with cisapride. Abnormal patterns of EGG were found in 78.3% of CF patients compared to 31.3% of controls during fasting (p<or=0.003) and in 56.5% of CF patients compared to 15.7% in healthy controls postprandially (p<or=0.018). In the CF patients, dysmotility consisted mostly of bradygastria during both fasting (16 of 18 with abnormal EGG) and postprandially (12 of 13 [92....Continue Reading

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Citations

Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Leah R ReznikovMichael J Welsh
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