Impaired glucose absorption in children with severe malnutrition

The Journal of Pediatrics
Robert H J BandsmaGeert Tom Heikens

Abstract

To quantify intestinal glucose absorption in children with two types of severe malnutrition, kwashiorkor and marasmus, compared with healthy children. Children with kwashiorkor (n = 6) and marasmus (n = 9) and control subjects (n = 3) received a primed (13 mg/kg), constant infusion (0.15 mg/kg/min) of [6,6H2]glucose for 4.5 hours. Two hours after start of the infusion an oral bolus of glucose 1.75 g/kg labeled with [U-13C]glucose 10 mg/g was given and was followed by periodic blood sampling. Mathematical modeling was applied to determine oral glucose absorption. Median total glucose absorption was 5.9 mmol/kg, interquartile range (IQR) 4.5-6.7 mmol/kg and 4.4 (IQR 2.9-5.9) mmol/kg in children with kwashiorkor and marasmus compared with 7.7 (IQR 5.8-9.0) mmol/kg in control subjects; P = .03 compared with marasmus). Children with the lowest glucose absorption were found specifically in the kwashiorkor group and marasmic children with hypoalbuminemia. Severe impairment in absorption correlated with urinary 8-hydroxydeoxyguanosine secretion (r = -0.62, P = .01). Severe malnutrition is associated with an impaired glucose absorption and decreased glucose absorption correlates with oxidative stress in these children.

References

Feb 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·P B SullivanG Neale
Feb 1, 1987·The Proceedings of the Nutrition Society·M H Golden, D Ramdath
Sep 11, 1965·Lancet·J P StanfieldR Tunnicliffe
Nov 1, 1973·The American Journal of Clinical Nutrition·M GraceyD E Stone
Oct 1, 1972·The American Journal of Clinical Nutrition·R E Schneider, F E Viteri
Feb 1, 1967·The American Journal of Clinical Nutrition·M D BowieJ D Hansen
Jan 1, 1993·Annals of Tropical Paediatrics·A A SiveH D Heese
Aug 1, 1993·American Journal of Public Health·D L PelletierJ P Habicht
Dec 10, 1999·Journal of Gastroenterology·M Khin Thein-Thein-Myint
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·A NataliAndrea Mari
Sep 2, 2000·The Journal of Pediatrics·Mark ManaryJ W Heinecke
Jun 29, 2001·Journal of Pediatric Gastroenterology and Nutrition·Beatrice AmadiC Chintu
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anup RamachandranKunissery A Balasubramanian
Aug 29, 2002·The American Journal of Clinical Nutrition·Asha BadalooFarook Jahoor
Jun 12, 2003·Computer Methods and Programs in Biomedicine·Andrea MariA W Thorburn
Nov 11, 2003·Qualitative Health Research·Stephanie Nixon, Rebecca Renwick
Jan 7, 2004·Analytical Biochemistry·Theo van DijkDirk-Jan Reijngoud
Nov 2, 2005·Redox Report : Communications in Free Radical Research·K BeckerR H Schirmer
Jan 22, 2008·Lancet·Robert E BlackMaternal and Child Undernutrition Study Group

Citations

May 19, 2012·AIDS Research and Treatment·Indi TrehanGeert Tom Heikens
Mar 6, 2012·Metabolism: Clinical and Experimental·Martijn N SpoelstraRobert H J Bandsma
Nov 19, 2015·Nutrition Reviews·Matilda A KvissbergRobert H J Bandsma
Sep 22, 2012·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Erika D SchroederGlobal Emergency Medicine Literature Review (GEMLR) Group
Aug 30, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Heitor Pons LeiteWerther Brunow de Carvalho
Oct 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Rosalie H BartelsWieger P Voskuijl
Feb 13, 2014·The Journal of Clinical Endocrinology and Metabolism·Patrice M Francis-EmmanuelMichael S Boyne
Sep 22, 2017·Nature Reviews. Disease Primers·Zulfiqar A BhuttaAndré Briend
Jul 11, 2015·American Journal of Physiology. Endocrinology and Metabolism·Robert H J BandsmaGary F Lewis
Jul 9, 2020·Anesthesia and Analgesia·Lori Q RieggerShobha Malviya
Sep 16, 2017·The Journal of Pediatrics·Rosalie H BartelsWieger P Voskuijl

Related Concepts

Blood Glucose
Gluconeogenesis
Glucose, (beta-D)-Isomer
Intravenous Infusion Procedures
Intestinal Absorption
Kwashiorkor
Marasmus
Severity of Illness Index
Nested Case-Control Studies
Oxidative Stress

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

The Journal of Pediatrics
Edward Vincent Faustino, Michael Apkon
Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Vijay SrinivasanVinay Nadkarni
© 2021 Meta ULC. All rights reserved