Abstract
We evaluated data from 10,088 participants without cardiovascular disease (CVD) who underwent 75 g oral glucose tolerance tests and had more than four visits during the first 5 years following the test to investigate the association between impaired glucose metabolism and visit-to-visit blood pressure (BP) variability. Participants were classified into groups of normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes. Visit-to-visit BP variability was estimated for each individual using standard deviation (SD) and coefficients of variation (CV, defined as SD/mean). SDs and CVs of systolic BP (SBP) values were divided into quartiles. The samples falling in the highest quartile were considered as having high SD/CV. The adjusted odds ratio (OR) for high SD of SBP in the IFG (OR, 1.39; P < 0.003), IGT (OR, 1.26; P < 0.001), and diabetes (OR, 1.54; P < 0.001) groups was significantly higher than that for high SD of SBP in the NGT group. Similarly, the OR for high CV of SBP in the IGT and diabetes groups was significantly higher than that for high CV of SBP in the NGT group. In participants without CVD, impaired glucose metabolism may modulate visit-to-visit BP variability.
References
Jul 1, 1988·Journal of Hypertension·J S FlorasP Sleight
Dec 16, 1997·American Journal of Hypertension·Y ImaiS Hisamichi
Jun 18, 1999·Diabetes Care·M TominagaA Sekikawa
Jan 28, 2003·Diabetes Care·Hirofumi OhnishiKazuaki Shimamoto
Jun 2, 2005·Hypertension·Juan RuizDaniel Hayoz
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Louis MonnierClaude Colette
Aug 11, 2006·Current Opinion in Cardiology·Ding-Feng Su
Mar 17, 2010·Lancet·Peter M RothwellNeil R Poulter
Aug 28, 2010·Diabetes Care·Eric S KilpatrickStephen L Atkin
Aug 6, 2011·European Journal of Clinical Investigation·Yi-Ting HsiehMing-Chia Hsieh
Feb 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Chung-Hao LiChih-Jen Chang
Jan 24, 2013·Diabetes Care·Hiroshi OkadaNaoto Nakamura
Aug 9, 2013·Circulation·Jun HataUNKNOWN ADVANCE Collaborative Group
Oct 2, 2013·American Journal of Hypertension·Michiaki Nagai, Kazuomi Kario
Nov 1, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Panagiota PietriChristodoulos Stefanadis
Jan 11, 2014·Acta Diabetologica·Jin-Shang WuChih-Jen Chang
Jan 6, 2015·Atherosclerosis·Stuart B Prenner, Julio A Chirinos
May 20, 2015·Hypertension·Yuichiro YanoTsuyoshi Watanabe
Dec 3, 2015·BMJ Open Diabetes Research & Care·Toshiko TakaoYasuhiko Iwamoto
Nov 9, 2016·Sleep Medicine·Nobuo SasakiYasuki Kihara