Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay.

Journal of Burn Care & Research : Official Publication of the American Burn Association
Ricki Y FramDavid N Herndon

Abstract

Hyperglycemia, secondary to the hypermetabolic stress response, is a common occurrence after thermal injury. This stress response has been documented to persist up to 9 months postburn. The purpose of this study was to measure insulin sensitivity in severely burned children before discharge when wounds are 95% healed. Twenty-four children, aged 4 to 17 years, with burns > or = 40% TBSA underwent a 2-hour oral glucose tolerance test before discharge from the acute pediatric burn unit. Plasma glucose and insulin levels as well as the Homeostasis Model Assessment for Insulin Resistance (HOMAIR) were compared with published oral glucose tolerance test data from healthy, nonburned children. There was a significant difference between severely burned children and nonburned, healthy children with respect to the HOMAIR. Severely burned children had a HOMAIR of 3.53 +/- 1.62 compared with the value in nonburned, healthy children of 1.28 +/- 0.16 (P < .05). Insulin resistance secondary to the hypermetabolic stress response persists in severely burned children when burn wounds are at least 95% healed. The results of this study warrant future investigations into therapeutic options for the burned child during the rehabilitative phase of the...Continue Reading

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Citations

May 15, 2013·Burns : Journal of the International Society for Burn Injuries·Craig PorterElisabet Børsheim
Dec 8, 2011·Metabolism: Clinical and Experimental·Panagiota Pervanidou, George P Chrousos
Mar 5, 2016·Critical Care Medicine·Sarah RehouMarc G Jeschke
Aug 11, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Soman SenTina Palmieri
Aug 24, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Theresa MayesRichard J Kagan
Oct 12, 2011·Current Opinion in Critical Care·Frederick W Endorf, David Ahrenholz
Jun 23, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Robert P ClaytonCraig Porter

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